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680C91

CAS No. 163239-22-3

680C91 ( —— )

产品货号. M23731 CAS No. 163239-22-3

680C91 是一种有效的选择性 TDO 抑制剂,其 Ki 为 51 nM。

纯度: >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
规格 价格/人民币 库存 数量
2MG ¥308 有现货
5MG ¥413 有现货
10MG ¥680 有现货
25MG ¥1361 有现货
50MG ¥2203 有现货
100MG ¥3208 有现货
200MG 获取报价 有现货
500MG 获取报价 有现货
1G 获取报价 有现货

生物学信息

  • 产品名称
    680C91
  • 注意事项
    本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
  • 产品简述
    680C91 是一种有效的选择性 TDO 抑制剂,其 Ki 为 51 nM。
  • 产品描述
    680C91 is a potent and selective inhibitor of TDO, and its Ki is 51 nM.
  • 体外实验
    680C91 is a potent (Ki=51 nM) and selective TDO inhibitor with no inhibitory activity against indoleamine 2,3-dioxygenase, monoamine oxidase A and B, 5-HT uptake and 5-HT1A,1D,2A and 2C receptors at a concentration of 10 μM.680C91 inhibits the catabolism of tryptophan by rat liver cells and rat liver perfused in situ. Tdo2 could regulate cell proliferation and stimulate the expression of decidual marker Dtprp in the uterine stromal cells and decidual cells. Tdo2 inhibitor 680C91 also inhibits the prolifer ation activity of uterine decidual cells at 24 h.Treatment of leiomyoma smooth muscle cell (LSMC) and myometrial smooth muscle cell (MSMC) spheroids with 680C91 (25 and 50 μM) significantly represses the expression of collagen type I (COL1A1) and type III (COL3A1) in a dose-dependent manner. Cell Proliferation Assay Cell Line:Uterine stromal cells Concentration:0.01, 0.05, 0.1, 0.5, 1, 5, and 10?μM Incubation Time:24?hours Result:The proliferation activity of stromal cells was significantly decreased at 5 and 10?μM.Western Blot Analysis Cell Line:MSMC and LSMC.Incubation Time:48 hours Result:Significantly reduced the expression of COL1A1 and COL3A1 in LSMC spheroids with no significant effect on expression of these proteins in MSMC spheroids.
  • 体内实验
    680C91 (a dose of 15 mg/kg for acute treatment ) elevates tryptophan in brain. Animal Model:Male C57Bl6/NCrl mice aged 13-18 weeks Dosage:15 mg/kg Administration:Administered per os Result:Caused a significant increase in brain tryptophan.
  • 同义词
    ——
  • 通路
    Others
  • 靶点
    Other Targets
  • 受体
    TDO
  • 研究领域
    ——
  • 适应症
    ——

化学信息

  • CAS Number
    163239-22-3
  • 分子量
    238.26
  • 分子式
    C15H11FN2
  • 纯度
    >98% (HPLC)
  • 溶解度
    DMSO:48 mg/ml (201.46 mM); Ethanol:25 mg/ml (104.93 mM)
  • SMILES
    C1=CC(=CN=C1)/C=C/C2=CNC3=C2C=CC(=C3)F
  • 化学全称
    ——

运输与储存

  • 储存条件
    (-20℃)
  • 运输条件
    With Ice Pack
  • 稳定性
    ≥ 2 years

参考文献

1.M Salter, et al. Biochem Pharmacol. 1995 May 17;49(10):1435-42.
产品手册
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