6-Methoxydihydrosanguinarine
CAS No. 72401-54-8
6-Methoxydihydrosanguinarine ( —— )
产品货号. M22599 CAS No. 72401-54-8
6-Methoxydihydrosanguinarine is a natural product.?6-Methoxydihydrosanguinarine shows strong cytotoxicity against MCF-7 and SF-268 cell lines with IC50 values of 0.61 μM and 0.54 μM, respectively.
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
规格 | 价格/人民币 | 库存 | 数量 |
5MG | ¥2989 | 有现货 |
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10MG | ¥4390 | 有现货 |
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25MG | ¥6982 | 有现货 |
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50MG | ¥9396 | 有现货 |
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100MG | ¥12636 | 有现货 |
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200MG | 获取报价 | 有现货 |
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500MG | 获取报价 | 有现货 |
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1G | 获取报价 | 有现货 |
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生物学信息
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产品名称6-Methoxydihydrosanguinarine
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注意事项本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
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产品简述6-Methoxydihydrosanguinarine is a natural product.?6-Methoxydihydrosanguinarine shows strong cytotoxicity against MCF-7 and SF-268 cell lines with IC50 values of 0.61 μM and 0.54 μM, respectively.
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产品描述6-Methoxydihydrosanguinarine is a natural product.?6-Methoxydihydrosanguinarine shows strong cytotoxicity against MCF-7 and SF-268 cell lines with IC50 values of 0.61 μM and 0.54 μM, respectively.It has antibacterial activity against Methicillin-resistant Staphylococcus aureus (MRSA) strains with minimum inhibitory concentrations (MICs) ranging from1.9 to 3.9 microg/ml6-methoxydihydrosanguinarine (6ME), a benzophenanthridine alkaloid isolated from Hylomecon species, may have potential as a chemotherapeutic agent.??6ME inhibits the growth of HepG2 cells in a concentration- and time-dependent manner (IC50=3.8+/-0.2 microM following 6 h incubation).?Treatment of HepG2 cells with 6ME resulted in the release of mitochondrial cytochrome c followed by the activation of caspase proteases, and subsequent proteolytic cleavage of poly(ADP-ribose) polymerase.?6ME increased the expression of p53 and bax and decreased the expression of bcl-2.?The cytotoxic effect of 6ME is mediated by the time-dependent generation of reactive oxygen species.?Preincubation of HepG2 cells with vitamin C decreased the expression of p53 and bax and inhibited the release of cytochrome c, activation of downstream caspase and the cleavage of poly(ADP-ribose) polymerase, thus inhibiting the apoptosis inducing effect of 6ME.
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同义词——
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通路Others
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靶点Other Targets
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受体Others
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研究领域——
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适应症——
化学信息
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CAS Number72401-54-8
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分子量363.36
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分子式C21H17NO5
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纯度>98% (HPLC)
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溶解度——
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SMILESCOC1N(C)c2c(ccc3cc4OCOc4cc23)-c2ccc3OCOc3c12
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Yin H Q , Kim Y H , Moon C K , et al. Reactive oxygen species-mediated induction of apoptosis by a plant alkaloid 6-methoxydihydrosanguinarine in HepG2 cells[J]. Biochemical Pharmacology, 2005, 70(2):242-248.
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