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6-Methoxydihydrosanguinarine

CAS No. 72401-54-8

6-Methoxydihydrosanguinarine ( —— )

产品货号. M22599 CAS No. 72401-54-8

6-Methoxydihydrosanguinarine is a natural product.?6-Methoxydihydrosanguinarine shows strong cytotoxicity against MCF-7 and SF-268 cell lines with IC50 values of 0.61 μM and 0.54 μM, respectively.

纯度: >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
规格 价格/人民币 库存 数量
5MG ¥2989 有现货
10MG ¥4390 有现货
25MG ¥6982 有现货
50MG ¥9396 有现货
100MG ¥12636 有现货
200MG 获取报价 有现货
500MG 获取报价 有现货
1G 获取报价 有现货

生物学信息

  • 产品名称
    6-Methoxydihydrosanguinarine
  • 注意事项
    本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
  • 产品简述
    6-Methoxydihydrosanguinarine is a natural product.?6-Methoxydihydrosanguinarine shows strong cytotoxicity against MCF-7 and SF-268 cell lines with IC50 values of 0.61 μM and 0.54 μM, respectively.
  • 产品描述
    6-Methoxydihydrosanguinarine is a natural product.?6-Methoxydihydrosanguinarine shows strong cytotoxicity against MCF-7 and SF-268 cell lines with IC50 values of 0.61 μM and 0.54 μM, respectively.It has antibacterial activity against Methicillin-resistant Staphylococcus aureus (MRSA) strains with minimum inhibitory concentrations (MICs) ranging from1.9 to 3.9 microg/ml6-methoxydihydrosanguinarine (6ME), a benzophenanthridine alkaloid isolated from Hylomecon species, may have potential as a chemotherapeutic agent.??6ME inhibits the growth of HepG2 cells in a concentration- and time-dependent manner (IC50=3.8+/-0.2 microM following 6 h incubation).?Treatment of HepG2 cells with 6ME resulted in the release of mitochondrial cytochrome c followed by the activation of caspase proteases, and subsequent proteolytic cleavage of poly(ADP-ribose) polymerase.?6ME increased the expression of p53 and bax and decreased the expression of bcl-2.?The cytotoxic effect of 6ME is mediated by the time-dependent generation of reactive oxygen species.?Preincubation of HepG2 cells with vitamin C decreased the expression of p53 and bax and inhibited the release of cytochrome c, activation of downstream caspase and the cleavage of poly(ADP-ribose) polymerase, thus inhibiting the apoptosis inducing effect of 6ME.
  • 同义词
    ——
  • 通路
    Others
  • 靶点
    Other Targets
  • 受体
    Others
  • 研究领域
    ——
  • 适应症
    ——

化学信息

  • CAS Number
    72401-54-8
  • 分子量
    363.36
  • 分子式
    C21H17NO5
  • 纯度
    >98% (HPLC)
  • 溶解度
    ——
  • SMILES
    COC1N(C)c2c(ccc3cc4OCOc4cc23)-c2ccc3OCOc3c12
  • 化学全称
    ——

运输与储存

  • 储存条件
    (-20℃)
  • 运输条件
    With Ice Pack
  • 稳定性
    ≥ 2 years

参考文献

1. Yin H Q , Kim Y H , Moon C K , et al. Reactive oxygen species-mediated induction of apoptosis by a plant alkaloid 6-methoxydihydrosanguinarine in HepG2 cells[J]. Biochemical Pharmacology, 2005, 70(2):242-248.
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