6-Aminochrysene ( —— )

产品货号. M33197 CAS No. 2642-98-0

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HNMR

HPLC

MSDS

Handing Instructions

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产品名称

6-Aminochrysene
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

6-Aminochrysene (6-Aminochrysene) 是芳香胺类化合物，可用于脾肿大，骨髓性白血病和乳腺癌的研究。
产品描述

6-Aminochrysene (6-Aminochrysene) is an aromatic amine used as a chemotherapeutic agent in the treatment of splenomegaly, myeloid leukemia, and breast cancer.
体外实验

6-Aminochrysene inhibits the hydroxylation of aniline, 0-demethylation of p-nitroanisole, and N-demethylation of aminopyrine by rat liver microsomes. Pre-treatment of rats with 6-aminochrysene markedly decreases the N-demethylation in vitro but significantly increases the hydroxylation and the 0-demethylation.
体内实验

6-Aminochrysene is an inhibitor of the growth of several solid experimental tumours in vivo and has a cancerostatic effect on human breast cancer. Long term topical skin application of 6-Aminochrysene to mice induces development of benign skin tumors after 3 months and of skin malignancies after 7 months. Female mice respond earlier than males. Induction of skin tumors is more rapid when 6-Aminochrysene is applied ventrally instead of dorsally. Urinary excretion is about twice as high after skin application than after oral administration.
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研究领域

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适应症

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1. Russo R, et al. Effects of 6-aminochrysene on liver microsomal enzyme activity. Xenobiotica. 1976 Apr;6(4):201-5.?

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