5-Methoxytryptophol ( Methoxytryptophol; 2-(5-Methoxy-1H-indol-3-yl)ethanol )

产品货号. M26544 CAS No. 712-09-4

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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产品名称

5-Methoxytryptophol
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

5-Methoxytryptophol is a pineal indoleamine derived from serotonin shown to be biologically active in a number of species.
产品描述

5-Methoxytryptophol is a pineal indoleamine derived from serotonin shown to be biologically active in a number of species.(In Vitro):In MC3T3-E1 cells, most of the 5-methoxytryptophol doses reduced slightly the metabolic activity of osteoblasts. After 14 days of cell culture, Rankl mRNA levels were decreased. 5-methoxytryptophol also induced a high osteocalcin secretion and mineralization capacity. In RAW264.7 cells, 5-methoxytryptophol decreased the number of osteoclast formed and its activity. 5-methoxytryptophol promoted activation of the ERK1/2 pathway through the phosphorylation of ERK, while LUZ addition suppressed this effect. In conclusion, 5-methoxytryptophol inhibits osteoclastogenesis and promoting osteoblast differentiation.
同义词

Methoxytryptophol; 2-(5-Methoxy-1H-indol-3-yl)ethanol
通路

Proteasome/Ubiquitin
靶点

Endogenous Metabolite
受体

NSD2-PWWP1
研究领域

——
适应症

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1.Dilworth D, et al. A chemical probe targeting the PWWP domain alters NSD2 nucleolar localization. Nat Chem Biol. 2022 Jan;18(1):56-63.

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