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4-IPP
CAS No. 41270-96-6
4-IPP ( 4-Iodo-6-phenylpyrimidine )
产品货号. M21584 CAS No. 41270-96-6
4-IPP 是巨噬细胞迁移抑制因子 (MIF) 的不可逆抑制剂。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 5MG | ￥786 | 有现货 |
|
| 10MG | ￥1320 | 有现货 |
|
| 25MG | ￥2236 | 有现货 |
|
| 50MG | ￥3216 | 有现货 |
|
| 100MG | ￥4763 | 有现货 |
|
| 200MG | 获取报价 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称4-IPP
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述4-IPP 是巨噬细胞迁移抑制因子 (MIF) 的不可逆抑制剂。
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产品描述4-IPP is an irreversible?inhibitor of macrophage migration inhibitory factor (MIF).
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体外实验Cell Cytotoxicity Assay Cell Line:BMMs Concentration:0.5 μM, 1 μM, 2.5 μM, 5 μM, 10 μM, 25 μM, 50 μM, 100 μM, 200 μM Incubation Time:24 hours, 72 hours Result:Inhibited osteoclastogenesis in a dose-dependent manner.Western Blot Analysis Cell Line:BMMs Concentration:5 μM,10 μM, 20 μM Incubation Time:1 day, 3 days, 5 days Result:Inhibited RANKL-induced osteoclast differentiation and bone resorption.
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体内实验Animal Model:8-weeks-old C57BL/6J male mice Dosage:1 mg/kg, 5 mg/kg Administration:Intraperitoneal injection; every 2 days; for 8 weeks Result:Alleviated OVX-induced osteoporosis.
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同义词4-Iodo-6-phenylpyrimidine
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通路Others
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靶点Other Targets
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受体MIF
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研究领域——
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适应症——
化学信息
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CAS Number41270-96-6
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分子量282.08
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分子式C10H7IN2
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纯度>98% (HPLC)
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溶解度In Vitro:?DMSO : 100 mg/mL (354.51 mM)
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SMILESIc1cc(ncn1)-c1ccccc1
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化学全称4-Iodo-6-phenyl-pyrimidine
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1.Zheng L et al. Macrophage migration inhibitory factor (MIF) inhibitor 4-IPP suppresses osteoclast formation and promotes osteoblast differentiation through the inhibition of the NF-κB signaling pathway. FASEB J. 2019 Jun;33(6):7667-7683.
产品手册
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