
3-Isomangostin
CAS No. 19275-46-8
3-Isomangostin ( —— )
产品货号. M27955 CAS No. 19275-46-8
3-Isomangostin 是一种乙酰胆碱酯酶选择性抑制剂和有效的人醛糖还原酶抑制剂,IC50 为 3.48 uM。
纯度: >98% (HPLC)






规格 | 价格/人民币 | 库存 | 数量 |
5MG | ¥2697 | 有现货 |
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10MG | ¥4601 | 有现货 |
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25MG | ¥7266 | 有现货 |
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50MG | ¥9558 | 有现货 |
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100MG | ¥13203 | 有现货 |
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200MG | 获取报价 | 有现货 |
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500MG | 获取报价 | 有现货 |
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1G | 获取报价 | 有现货 |
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生物学信息
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产品名称3-Isomangostin
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注意事项本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
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产品简述3-Isomangostin 是一种乙酰胆碱酯酶选择性抑制剂和有效的人醛糖还原酶抑制剂,IC50 为 3.48 uM。
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产品描述3-Isomangostin is an acetylcholinesterase selective inhibitor and a potent human aldose reductase inhibitor with an IC50 of 3.48 uM. 3-Isomangostin has free radical scavenging activity and inhibits MutT homolog 1 (MTH1) with an IC50 of 52 nM. It shows antiplasmodial activity with an IC50 values in the range of 4.71-11.40 uM. 3-Isomangostin can be used to develop anticancer agents as well.(In Vitro):Species of Garcinia have been used to combat malaria in traditional African and Asian medicines, including Ayurveda. In the current study, we have identified antiplasmodial benzophenone and xanthone compounds from edible Garcinia species by testing for in vitro inhibitory activity against Plasmodium falciparum. Whole fruits of Garcinia xanthochymus, G. mangostana, G. spicata, and G. livingstonei were extracted and tested for antiplasmodial activity. Garcinia xanthochymus was subjected to bioactivity-guided fractionation to identify active partitions. Purified benzophenones (1-9) and xanthones (10-18) were then screened in the plasmodial lactate dehydrogenase assay and tested for cytotoxicity against mammalian (Vero) cells. The benzophenones guttiferone E (4), isoxanthochymol (5), and guttiferone H (6), isolated from G. xanthochymus, and the xanthones α-mangostin (15), β-mangostin (16), and 3-Isomangostin (17), known from G. mangostana, showed antiplasmodial activity with an IC50 values in the range of 4.71-11.40 μM. Artemisinin and chloroquine were used as positive controls and exhibited an IC50 values in the range of 0.01-0.24 μM.
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体外实验——
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体内实验——
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同义词——
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通路Others
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靶点Other Targets
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受体Antibiotic|Bacterial
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研究领域——
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适应症——
化学信息
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CAS Number19275-46-8
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分子量410.46
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分子式C24H26O6
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纯度>98% (HPLC)
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溶解度In Vitro:?DMSO : 100 mg/mL (243.63 mM)
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SMILESCC(C)(CC1)Oc(cc2Oc(cc3O)c4c(CC=C(C)C)c3OC)c1c(O)c2C4=O
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1.Bhuta P, et al. Analogues of chloramphenicol: circular dichroism spectra, inhibition of ribosomal peptidyltransferase, and possible mechanism of action. J Med Chem. 1980 Dec;23(12):1299-305.
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