25-Hydroxycholesterol ( —— )

产品货号. M19577 CAS No. 2140-46-7

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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产品名称

25-Hydroxycholesterol
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

25-Hydroxycholesterol 是一种类固醇衍生物，可抑制甾醇调节元件结合蛋白 (SREBP) 的裂解。
产品描述

25-Hydroxycholesterol is a steroid derivative that suppresses the cleavage of sterol regulatory element binding proteins (SREBPs). It inhibits HMG-CoA reductase and so it also plays a significant role in the in vivo regulation of cholesterol biosynthesis after an acute dietary cholesterol challenge. 25-hydroxycholesterol is a potent (EC50≈65 nM) and selective suppressor of IgA production by B cells.
体外实验

The synthesis of 25-hydroxycholesterol is catalyzed by the enzyme cholesterol 25-hydroxylase, which uses cholesterol and molecular oxygen as substrates and NADPH as a cofactor. 25-hydroxycholesterol is a potent bioactive lipid in the innate and adaptive immune systems.
体内实验

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同义词

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通路

Others
靶点

Other Targets
受体

other| HMG-CoA Reductase
研究领域

——
适应症

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CAS Number

2140-46-7
分子量

402.65
分子式

C27H46O2
纯度

>98% (HPLC)
溶解度

Ethanol: 20 mg/mL;Chloroform: 50 mg/mL
SMILES

C[C@H](CCCC(C)(C)O)[C@H]1CC[C@H]2[C@@H]3CC=C4C[C@@H](O)CC[C@]4(C)[C@H]3CC[C@]12C
化学全称

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1.McDonald JG et al. Editorial: 25-Hydroxycholesterol: a new life in immunology. J Leukoc Biol. 2010 Dec;88(6):1071-2.

计算器

产品手册

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