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2-Methoxyestradiol
CAS No. 362-07-2
2-Methoxyestradiol ( 2ME2 | NSC-659853 )
产品货号. M14242 CAS No. 362-07-2
2-Methoxyestradiol (2ME2;NSC-659853) 是 estradiol-17β 的代谢产物，是一种新型抗有丝分裂、抗血管生成剂。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 50MG | ￥405 | 有现货 |
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| 100MG | ￥470 | 有现货 |
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| 200MG | 获取报价 | 有现货 |
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| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称2-Methoxyestradiol
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述2-Methoxyestradiol (2ME2;NSC-659853) 是 estradiol-17β 的代谢产物，是一种新型抗有丝分裂、抗血管生成剂。
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产品描述2-Methoxyestradiol (2ME2;NSC-659853) is a metabolite of estradiol-17β and a novel antimitotic, antiangiogenic agent, binds to tubulin at or near the colchicine site and inhibits the polymerization of tubulin in vitro; suppresses microtubule dynamic instability in living interphase cells with mitotic IC50 of 1.2 uM, inhibits bFGF and VEGF-induced neovascularization and suppresses the growth of human breast carcinoma in mice; also downregulates hypoxia-inducible factor-1 (HIF) at the posttranscriptional level and inhibits HIF-1-induced transcriptional activation of VEGF expression.
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体外实验——
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体内实验——
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同义词2ME2 | NSC-659853
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通路Angiogenesis
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靶点HIF/HIF Prolyl-hydroxylase
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受体HIF-1α|HIF-2α|Microtubuledepolymerization
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研究领域Cancer
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适应症——
化学信息
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CAS Number362-07-2
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分子量302.4079
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分子式C19H26O3
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纯度>98% (HPLC)
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溶解度DMSO: ≥ 36 mg/mL; H2O: < 0.1 mg/mL
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SMILESOC1=C(OC)C=C2[C@@]3([H])CC[C@]4(C)[C@@H](O)CC[C@@]4([H])[C@]3([H])CCC2=C1
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化学全称Estra-1,3,5(10)-triene-3,17-diol, 2-methoxy-, (17.beta.)-
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Klauber N, et al. Mol Cancer Ther. 2006 Sep;5(9):2225-33.
2. Cushman M, et al. J Med Chem. 1995 Jun 9;38(12):2041-9.
3. Klauber N, et al. Cancer Res. 1997 Jan 1;57(1):81-6.
4. Mabjeesh NJ, et al. Cancer Cell. 2003 Apr;3(4):363-75.
产品手册
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