2-Hydroxybenzylamine
CAS No. 932-30-9
2-Hydroxybenzylamine ( —— )
产品货号. M28366 CAS No. 932-30-9
2-Hydroxybenzylamine, a potent small molecule scavenger of IsoLGs, sequesters the reactive species as inert adducts.
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
规格 | 价格/人民币 | 库存 | 数量 |
500MG | ¥462 | 有现货 |
|
1G | ¥737 | 有现货 |
|
生物学信息
-
产品名称2-Hydroxybenzylamine
-
注意事项本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
-
产品简述2-Hydroxybenzylamine, a potent small molecule scavenger of IsoLGs, sequesters the reactive species as inert adducts.
-
产品描述2-Hydroxybenzylamine, a potent small molecule scavenger of IsoLGs, sequesters the reactive species as inert adducts. 2-Hydroxybenzylamine may be used to decrease early recurrence of atrial fibrillation and other atrial arrhythmias following atrial fibrillation ablation by decreasing IsoLG adducts with native biomolecules.(In Vivo):Compared to hypercholesterolemic Ldlr-/- mice treated with vehicle or 4-Hydroxybenzylamine, a nonreactive analogue, 2-Hydroxybenzylamine decreases atherosclerosis by 60% in en face aortas, without changing plasma cholesterol. Ldlr-/- mice treated with 2-Hydroxybenzylamine have reduced MDA-LDL and MDA-HDL levels, and their HDL display increased capacity to reduce macrophage cholesterol. Importantly, 2-Hydroxybenzylamine reduces the MDA- and IsoLG-lysyl content in atherosclerotic aortas versus 4-Hydroxybenzylamine. Furthermore, 2-Hydroxybenzylamine reduces inflammation and plaque apoptotic cells and promotes efferocytosis and features of stable plaques. Dicarbonyl scavenging with 2-Hydroxybenzylamine has multiple atheroprotective effects in a murine FH model.
-
同义词——
-
通路Others
-
靶点Other Targets
-
受体SIRT1
-
研究领域——
-
适应症——
化学信息
-
CAS Number932-30-9
-
分子量123.2
-
分子式C7H9NO
-
纯度>98% (HPLC)
-
溶解度——
-
SMILESNCc1ccccc1O
-
化学全称——
运输与储存
-
储存条件(-20℃)
-
运输条件With Ice Pack
-
稳定性≥ 2 years
参考文献
1.Arunasree M Kalle, et al. Inhibition of SIRT1 by a small molecule induces apoptosis in breast cancer cells. Biochem Biophys Res Commun. 2010 Oct 8;401(1):13-9.
产品手册
关联产品
-
Loureirin C
Loureirin C can inhibit the activities of thrombin in vitro effectively.
-
Kemantane
Idramantone is an immune agonist.
-
Hederagenin 3-O-(2-O...
Hederagenin 3-O-(2-O-acetyl-α-L-arabinopyranoside) significantly increased alkaline phosphatase (ALP) activity and the level of protein expression of bone sialoprotein (BSP) and osteocalcin (OC) .