2,7-dihydroxy-3,4-dimethoxyphenanthrene

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Nudol 是一种具有抗癌活性的菲 (phenanthrene) 化合物。Nudol 抑制细胞增殖，诱导细胞凋亡 (apoptosis)。Nudol 抑制 MMP-2 和 MMP-9 活性 (Ki 值分别为 988.9 nM 和 1.76 μM)。Nudol 可用于骨肉瘤等癌症的研究。

Nudol is a phenanthrene compound that has anti-cancer activity. Nudol inhibits cell proliferation, induces cell apoptosis. Nudol inhibits MMP-2M and MMP-9 activity (Ki: 988.9 nM, 1.76 μM, respectively). Nudol can be used in the research of cancers, such as osteosarcoma.

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Nudol (0-40 μM, 24-72 h) decreases cell viability in several cancer cell lines.Nudol (0-20 μM, 24/48 h) suppresses the cell migration and causes cell cycle arrest at G2/M phase in U2OS cells.Nudol (20 μM, 48 h) induces cell apoptosis through the caspase-dependent pathway in U2OS cells.Nudol (compound 4) inhibits MMP-2 and MMP-9 activity with Ki values of 988.9 nM and 1.76 μM respectively.Cell Viability Assay Cell Line:U2OS, MG63, MDA-MB-231, MCF-7, and A549 cells Concentration:0, 10, 20, 30, 40 μM Incubation Time:24, 48, and 72 h Result:Decreased the cell viability of osteosarcoma cells in dose- and time-dependent manners.Cell Cycle Analysis Cell Line:U2OS cells Concentration:0, 5, 10, 20 μM Incubation Time:24, 48, and 72 h Result:Triggered G2/M phase arrest by decreasing cell cycle-related proteins (CDK1, CDK2, CDK4, and CDK10).Western Blot Analysis Cell Line:U2OS cells Concentration:0, 5, 10, 20, 40 μM Incubation Time:24, 48, and 72 h Result:Increased the protein level of cytochrome c.Down-regulated anti-apoptotic Bcl-2, accompanied by an increased level of pro-apoptotic Bax.

2,7-二羟基-3,4-二甲氧基菲

Others

Other Targets

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86630-46-8

270.279

C16H14O4

>98% (HPLC)

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(-20℃)

With Ice Pack

≥ 2 years