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1-Adamantylamine

CAS No. 768-94-5

1-Adamantylamine ( Amantadine | 1-Adamantanamine | 1-Aminoadamantane )

产品货号. M21211 CAS No. 768-94-5

1-Adamantylamine 是一种抗病毒药,是 NMDA 型谷氨酸受体的弱拮抗剂,可增加多巴胺释放并阻止多巴胺再摄取。

纯度: >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
规格 价格/人民币 库存 数量
500MG ¥316 有现货
1G 获取报价 有现货

生物学信息

  • 产品名称
    1-Adamantylamine
  • 注意事项
    本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
  • 产品简述
    1-Adamantylamine 是一种抗病毒药,是 NMDA 型谷氨酸受体的弱拮抗剂,可增加多巴胺释放并阻止多巴胺再摄取。
  • 产品描述
    1-Adamantylamine is an antiviral is a weak antagonist of the NMDA-type glutamate receptor increases dopamine release and blocks dopamine reuptake.?(In Vitro):Amantadine (0-500 μM, 26 h) inhibits SARS-CoV-2 replication, with IC50 concentrations between 83 and 119 μM.Amantadine (0-100 μg/mL, 24-72 h) markedly inhibits the proliferation of HepG2 and SMMC?7721 cells.Amantadine (0-75 μg/mL, 48 h) arrests the cell cycle at the G0/G1 phase and induces apoptosis.Amantadine (0-75 μg/mL, 48 h) reduces the levels of the cell cycle?related genes and proteins (cyclin D1, cyclin E and CDK2), reduces Bcl-2 and increases the Bax protein and mRNA levels.(In Vivo):Amantadine (25 mg/kg, IP, once daily for 3 days) inhibits surgery induced neuroinflammation and learning and memory impairment.
  • 体外实验
    Amantadine (0-500 μM, 26 h) inhibits SARS-CoV-2 replication, with IC50 concentrations between 83 and 119 μM. Amantadine (0-100 μg/mL, 24-72 h) markedly inhibits the proliferation of HepG2 and SMMC?7721 cells. Amantadine (0-75 μg/mL, 48 h) arrests the cell cycle at the G0/G1 phase and induces apoptosis.Amantadine (0-75 μg/mL, 48 h) reduces the levels of the cell cycle?related genes and proteins (cyclin D1, cyclin E and CDK2), reduces Bcl-2 and increases the Bax protein and mRNA levels. Cell Viability Assay Cell Line:Vero E6 cells Concentration:500 μM, 100 μM, 20 μM, 4 μM, and 8 nM Incubation Time:26 h Result:Caused a concentration-dependent reduction (IC50=83 μM) of viral nucleic acids in the supernatant 26 h after infection at 10-500 μM. Caused a concentration-dependent reduction (IC50=119 μM) of viral nucleic acids in the cytosol 26 h after infection.Cell Proliferation Assay Cell Line:Human HCC cell lines (HepG2 and SMMC-7721) and normal hepatocellular cells (L02 cells) Concentration:0, 1, 2, 5, 10, 25, 50 and 100 μg/mL Incubation Time:24, 48 and 72 h Result:Inhibited cellular proliferation in a time- and dose-dependent manner in HepG2 and SMMC-7721 cells.Cell Cycle Analysis Cell Line:HepG2 and SMMC-7721 cells Concentration:0, 10, 25, 50 and 75 μg/mL Incubation Time:48 h Result:Significantly increased the population of HepG2 and SMMC-7721 cells in the G0/G1 phase in a dose-dependent manner, and significantly decreased the number of HepG2 cells in the S phase.Apoptosis Analysis Cell Line:HepG2 and SMMC-7721 cells Concentration:0, 10, 25, 50 and 75 μg/mL Incubation Time:48 h Result:Markedly increased the percentage of apoptotic HepG2 and SMMC-7721 cells (early- and late-stage apoptosis) in a dose-dependent manner.Western Blot Analysis Cell Line:HepG2 and SMMC-7721 cells Concentration:0, 10, 25, 50 and 75 μg/mL Incubation Time:48 h Result:Showed downregulation of cyclin D1, cyclin E and CDK2, and showed a decrease in Bcl-2 levels and an increase of Bax levels in HepG2 and SMMC-7721 cells. RT-PCR Cell Line:HepG2 and SMMC-7721 cells Concentration:0, 10, 25, 50 and 75 μg/mL Incubation Time:48 h Result:Revealed an increase in Bax and decrease in Bcl-2 genes.
  • 体内实验
    Amantadine (25 mg/kg, IP, once daily for 3 days) inhibits surgery induced neuroinflammation and learning and memory impairment. Animal Model:Fischer 344 rats (Four-month old, male, 290-330 g, 15 rats each group) Dosage:25 mg/kg Administration:IP, once daily for 3 days (the first dose at 15 min before surgery)Result:Inhibited surgery induced neuroinflammation and learning and memory impairment, increased GDNF (glial cell line-derived neurotrophic factor) that was co-localized with glial fibrillary acidic protein (an astrocytic marker) in the hippocampus.
  • 同义词
    Amantadine | 1-Adamantanamine | 1-Aminoadamantane
  • 通路
    Others
  • 靶点
    Other Targets
  • 受体
    Others
  • 研究领域
    Cardiovascular Disease
  • 适应症
    ComaHeart ArrestAnoxia

化学信息

  • CAS Number
    768-94-5
  • 分子量
    151.25
  • 分子式
    C10H17N
  • 纯度
    >98% (HPLC)
  • 溶解度
    DMSO:1 mg/mL (6.61 mM)
  • SMILES
    NC12CC3CC(CC(C3)C1)C2
  • 化学全称
    ——

运输与储存

  • 储存条件
    (-20℃)
  • 运输条件
    With Ice Pack
  • 稳定性
    ≥ 2 years

参考文献

1.Lim J K Wooten D Siegel R et al. Amantadine in treatment of chronic hepatitis C virus infection?[J]. Journal of Viral Hepatitis 2005 12(5):445-455.
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