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1,5-Isoquinolinediol

CAS No. 5154-02-9

1,5-Isoquinolinediol ( —— )

产品货号. M17727 CAS No. 5154-02-9

1, 5-Isoquinolinediol 是聚(ADP-核糖)合成酶(PARP1;IC50:0.39 μM)的抑制剂。

纯度: >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
规格 价格/人民币 库存 数量
5MG ¥470 有现货
10MG ¥705 有现货
50MG ¥1547 有现货
100MG 获取报价 有现货
200MG 获取报价 有现货
500MG 获取报价 有现货
1G 获取报价 有现货

生物学信息

  • 产品名称
    1,5-Isoquinolinediol
  • 注意事项
    本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
  • 产品简述
    1, 5-Isoquinolinediol 是聚(ADP-核糖)合成酶(PARP1;IC50:0.39 μM)的抑制剂。
  • 产品描述
    1, 5-Isoquinolinediol is an inhibitor of poly(ADP-ribose) synthetase (PARP1; IC50: 0.39 μM). The poly(ADP-ribose) polymerases (PARPs) form a family of enzymes with roles in DNA repair and apoptosis. 1, 5-Isoquinolinediol has been used to study the role of PARP1 in both DNA repair and oxidant stress-induced cell death. This compound can be used with cells in culture and in animals.
  • 体外实验
    1,5-isoquinolinediol leads to an increase up to 8-fold in the absolute frequency of gene targeting in the correction of the mutation at the stable integrated HSV tk gene.1,5-Isoquinolinediol is a potent PARP antagonist and decreases cleaved PARP in diabetic retina.1,5-Isoquinolinediol (500 μM H2O2; 24 hours) attenuates H2O2-induced upregulation of cleaved PARP-1 expression in retinal Muller cells. 1,5-Isoquinolinediol attenuates diabetes-induced upregulation of retinal nitrated protein expression. 1,5-Isoquinolinediol attenuates diabetes-induced activation of NADPH oxidase in the retina.
  • 体内实验
    ——
  • 同义词
    ——
  • 通路
    Others
  • 靶点
    Other Targets
  • 受体
    PARP1
  • 研究领域
    ——
  • 适应症
    ——

化学信息

  • CAS Number
    5154-02-9
  • 分子量
    161.16
  • 分子式
    C9H7NO2
  • 纯度
    >98% (HPLC)
  • 溶解度
    In Vitro:?DMSO : 37.04 mg/mL (229.83 mM)
  • SMILES
    Oc1cccc2c1cc[nH]c2=O
  • 化学全称
    ——

运输与储存

  • 储存条件
    (-20℃)
  • 运输条件
    With Ice Pack
  • 稳定性
    ≥ 2 years

参考文献

1. Davar D, et al. Role of PARP inhibitors in cancer biology and therapy.[J]. Current Medicinal Chemistry, 2012, 19(23).
产品手册
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