1,4-Anthraquinone

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

1,4-Anthraquinone 是一种抗癌化合物，可阻断核苷转运、抑制大分子合成、诱导 DNA 断裂。

1,4-Anthraquinone is an anticancer drug that blocks nucleoside transport, inhibits macromolecule synthesis, induces DNA fragmentation, and decreases the growth and viability of L1210 leukemic cells in the same nanomolar range as daunorubicin in vitro.1,4-Anthraquinone is proposed as a novel pre-column reagent for high performance liquid chromatography (HPLC) determination of N-acetylcysteine (NAC) and captopril (CAP) in pharmaceutical formulations.

1,4-Anthraquinone (2.62 nM-1.6 μM; 4 days) induces significant antiproliferative and cytotoxic effects in L1210 cells after 4 days at 6.55 nM; inhibits cell viability with IC50s of 100 nM at day 2 and 25 nM at day 4.1,4-Anthraquinone (40.96 nM-25 μM; 30 min; L1210 cells) inhibits nucleoside transport by 71 and 92% and DNA synthesis by 84 and 96% at 4 and 10 μM, respectively, and are both irreversible upon drug removal.1,4-Anthraquinone (0.1024-25 μM; 3 h) inhibits the rates of RNA and protein syntheses (IC50 = 2 μM) in a dose-dependent manner. Cell Proliferation Assay Cell Line:L1210 cells Concentration:2.62 nM-1.6 μM Incubation Time:4 days Result:Induced significant antiproliferative and cytotoxic effects after 4 days at 6.55 nM.Cell Viability Assay Cell Line:L1210 cells Concentration:2.62 nM-1.6 μM Incubation Time:4 days Result:Inhibited cell viability with IC50s of 100 nM at day 2 and 25 nM at day 4.

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Others

Other Targets

Others

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635-12-1

208.2

C14H8O2

>98% (HPLC)

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O=C(C=C1)c2cc3ccccc3cc2C1=O

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(-20℃)

With Ice Pack

≥ 2 years