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1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine
CAS No. 4004-05-1
1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine ( DOPE )
产品货号. M22918 CAS No. 4004-05-1
1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine is a neutral helper lipid for cationic liposomes.It is used in combination with cationic phospholipids to increase efficiency during DNA transfection studies as a non-viral method of gene delivery.
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 100MG | ￥786 | 有现货 |
|
| 200MG | 获取报价 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine is a neutral helper lipid for cationic liposomes.It is used in combination with cationic phospholipids to increase efficiency during DNA transfection studies as a non-viral method of gene delivery.
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产品描述1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine is a neutral helper lipid for cationic liposomes.It is used in combination with cationic phospholipids to increase efficiency during DNA transfection studies as a non-viral method of gene delivery.Each siRNA is encapsulated in LNP (cationic lipid-A: PEG2000-DMPE: DOPE = 47.8: 5.18: 47.1 molar percent). With the neutral lipid for the LNP is DOPE, LNP exerts knock-down (KD) effect on macrophages and DCs and Liposome-containing DOPE shows fusogenicity. LNP/siRNA significantly suppresses CD45 protein expression at an inhibition rate of 30% on macrophages and DCs but not on monocytes, neutrophils, plasmacytoid DCs, or B cells.
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同义词DOPE
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通路Others
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靶点Other Targets
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受体Others
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研究领域——
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适应症——
化学信息
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CAS Number4004-05-1
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分子量744.03
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分子式C41H78NO8P
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纯度>98% (HPLC)
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溶解度DMSO:31.25 mg/mL (42.00 mM; Need ultrasonic)
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SMILESO=P(OC[C@H](OC(CCCCCCC/C=C\CCCCCCCC)=O)COC(CCCCCCC/C=C\CCCCCCCC)=O)(OCCN)O
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Uemura Y, et al. The efficiency of lipid nanoparticles with an original cationic lipid as a siRNA delivery system for macrophages and dendritic cells.Pharm Dev Technol.2019 Mar;24(3):263-268.
产品手册
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