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1,2-Bis(2-iodoethoxy)ethane
CAS No. 36839-55-1
1,2-Bis(2-iodoethoxy)ethane ( —— )
产品货号. M26870 CAS No. 36839-55-1
1,2-双(2-碘乙氧基)乙烷是一种基于 PEG 的 PROTAC 连接剂。 1,2-双(2-碘乙氧基)乙烷可用于合成MT802和SJF620。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 500MG | ￥332 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称1,2-Bis(2-iodoethoxy)ethane
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述1,2-双(2-碘乙氧基)乙烷是一种基于 PEG 的 PROTAC 连接剂。 1,2-双(2-碘乙氧基)乙烷可用于合成MT802和SJF620。
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产品描述1,2-Bis(2-iodoethoxy)ethane is a PEG-based PROTAC linker. 1,2-Bis(2-iodoethoxy)ethane can be used in the synthesis of MT802 and SJF620. MT-802 and SJF620 are potent PROTAC BTK degraders with DC50s of 1 nM and 7.9 nM, respectively.(In Vitro):1,2-Bis(2-iodoethoxy)ethane is a PROTAC linker, which refers to the PEG composition. 1,2-Bis(2-iodoethoxy)ethane can be used in the synthesis of a series of PROTACs, such as MT802 and SJF620. PROTAC MT802 has a ligand specific for BTK, and a ligand specific to a E3 ligase cereblon (CRBN) connected by polyethylene glycol (PEG) linker 1,2-Bis(2-iodoethoxy)ethane.
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体外实验1,2-Bis(2-iodoethoxy)ethane is a PROTAC linker, which refers to the PEG composition. 1,2-Bis(2-iodoethoxy)ethane can be used in the synthesis of a series of PROTACs, such as MT802 (HY-122562) and SJF620 (HY-133137). PROTAC MT802（HY-122562） has a ligand specific for BTK, and a ligand specific to a E3 ligase cereblon (CRBN) connected by polyethylene glycol (PEG) linker 1,2-Bis(2-iodoethoxy)ethane.
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体内实验——
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同义词——
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通路Others
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靶点Other Targets
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受体——
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研究领域——
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适应症——
化学信息
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CAS Number36839-55-1
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分子量369.969
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分子式C6H12I2O2
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纯度>98% (HPLC)
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溶解度——
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SMILESICCOCCOCCI
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1.Chen M, et al. Protective effect of mitochondria?targeted peptide MTP?131 against oxidative stress?induced apoptosis in RGC?5 cells. Mol Med Rep. 2017 Apr;15(4):2179-2185.
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