(±)-Equol ( —— )

产品货号. M19273 CAS No. 94105-90-5

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HNMR

HPLC

MSDS

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产品名称

(±)-Equol
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

Equol is a non-steroidal estrogen produced from the metabolism of the isoflavonoid phytoestrogen daidzen by human intestinal microflora.
产品描述

Equol is a non-steroidal estrogen produced from the metabolism of the isoflavonoid phytoestrogen daidzen by human intestinal microflora.The estrogen receptor (ER) agonist activity of the naturally occurring (S)-enantiomer (EC50= 85 and 65 nM for human ERα and ERβ, respectively) is similar to that of genistein but exceeds that of daidzein.(S)-Equol preferentially binds ERβ (Ki= 0.73 nM) and demonstrates approximately 9-fold lower affinity for ERα (Ki= 6.41 nM).(S)-equol is also a potent antagonist of dihydrotestosterone, which has important implications for prostate cancer and other androgen-mediated pathologies.
同义词

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通路

Others
靶点

Other Targets
受体

ERα; ERβ
研究领域

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适应症

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1.Mahalingam S, Gao L, Gonnering M, Helferich W, et al.Toxicol Appl Pharmacol. 2016 Mar 15;295:47-55.

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