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首页- Products - Others - Other Targets - (S,R,S)-AHPC-Me

(S,R,S)-AHPC-Me

CAS No. 1948273-02-6

(S,R,S)-AHPC-Me ( VHL ligand 2; E3 ligase Ligand 1A )

产品货号. M28565 CAS No. 1948273-02-6

(S,R,S)-AHPC-Me (VHL ligand 2) is the (S,R,S)-AHPC-based VHL ligand used in the recruitment of the von Hippel-Lindau (VHL) protein. (S,R,S)-AHPC-Me can be used to synthesize ARV-771.

纯度: >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
规格 价格/人民币 库存 数量
10MG ￥316 有现货
25MG ￥583 有现货
50MG ￥883 有现货
100MG ￥1320 有现货
200MG ￥1968 有现货
500MG ￥3216 有现货
1G 获取报价 有现货
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生物学信息

  • 产品名称
    (S,R,S)-AHPC-Me
  • 注意事项
    本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
  • 产品简述
    (S,R,S)-AHPC-Me (VHL ligand 2) is the (S,R,S)-AHPC-based VHL ligand used in the recruitment of the von Hippel-Lindau (VHL) protein. (S,R,S)-AHPC-Me can be used to synthesize ARV-771.
  • 产品描述
    (S,R,S)-AHPC-Me (VHL ligand 2) is the (S,R,S)-AHPC-based VHL ligand used in the recruitment of the von Hippel-Lindau (VHL) protein. (S,R,S)-AHPC-Me can be used to synthesize ARV-771. ARV-771 is a von Hippel-Landau (VHL) E3 ligase-based BET PROTAC degrader. ARV-771 potently degrades BET protein in castration-resistant prostate cancer (CRPC) cells with a DC50 <1 nM.
  • 同义词
    VHL ligand 2; E3 ligase Ligand 1A
  • 通路
    Others
  • 靶点
    Other Targets
  • 受体
    α1A-adrenergic receptor
  • 研究领域
    ——
  • 适应症
    ——

化学信息

  • CAS Number
    1948273-02-6
  • 分子量
    444.6
  • 分子式
    C23H32N4O3S
  • 纯度
    >98% (HPLC)
  • 溶解度
    ——
  • SMILES
    C[C@H](NC(=O)[C@@H]1C[C@@H](O)CN1C(=O)[C@@H](N)C(C)(C)C)c1ccc(cc1)-c1scnc1C
  • 化学全称
    ——

运输与储存

  • 储存条件
    (-20℃)
  • 运输条件
    With Ice Pack
  • 稳定性
    ≥ 2 years

参考文献

1.Williams TJ, et al. In vitro alpha1-adrenoceptor pharmacology of Ro 70-0004 and RS-100329, novel alpha1A-adrenoceptor selective antagonists. Br J Pharmacol. 1999 May;127(1):252-8.
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