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(S,R,S)-AHPC-Me
CAS No. 1948273-02-6
(S,R,S)-AHPC-Me ( VHL ligand 2 | E3 ligase Ligand 1A )
产品货号. M28565 CAS No. 1948273-02-6
(S,R,S)-AHPC-Me（VHL 配体 2）是基于 (S,R,S)-AHPC 的 VHL 配体，用于招募 von Hippel-Lindau (VHL) 蛋白。 (S,R,S)-AHPC-Me可用于合成ARV-771。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 10MG | ￥316 | 有现货 |
|
| 25MG | ￥583 | 有现货 |
|
| 50MG | ￥883 | 有现货 |
|
| 100MG | ￥1320 | 有现货 |
|
| 200MG | ￥1968 | 有现货 |
|
| 500MG | ￥3216 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称(S,R,S)-AHPC-Me
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述(S,R,S)-AHPC-Me（VHL 配体 2）是基于 (S,R,S)-AHPC 的 VHL 配体，用于招募 von Hippel-Lindau (VHL) 蛋白。 (S,R,S)-AHPC-Me可用于合成ARV-771。
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产品描述(S,R,S)-AHPC-Me (VHL ligand 2) is the (S,R,S)-AHPC-based VHL ligand used in the recruitment of the von Hippel-Lindau (VHL) protein. (S,R,S)-AHPC-Me can be used to synthesize ARV-771. ARV-771 is a von Hippel-Landau (VHL) E3 ligase-based BET PROTAC degrader. ARV-771 potently degrades BET protein in castration-resistant prostate cancer (CRPC) cells with a DC50 <1 nM.
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体外实验——
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体内实验——
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同义词VHL ligand 2 | E3 ligase Ligand 1A
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通路Others
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靶点Other Targets
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受体α1A-adrenergic receptor
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研究领域——
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适应症——
化学信息
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CAS Number1948273-02-6
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分子量444.59
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分子式C23H32N4O3S
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纯度>98% (HPLC)
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溶解度In Vitro:?DMSO : 250 mg/mL (562.32 mM)
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SMILESC[C@H](NC(=O)[C@@H]1C[C@@H](O)CN1C(=O)[C@@H](N)C(C)(C)C)c1ccc(cc1)-c1scnc1C
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1.Williams TJ, et al. In vitro alpha1-adrenoceptor pharmacology of Ro 70-0004 and RS-100329, novel alpha1A-adrenoceptor selective antagonists. Br J Pharmacol. 1999 May;127(1):252-8.
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