(S)-Willardiine

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

(S)-Willardiine是AMPA/kainate受体有效激动剂，EC50值为44.8uM。

(S)-Willardiine is a potent agonist of AMPA/kainate receptors with EC50 of 44.8 uM.IC50 value: 44.8 uM(EC50) Target: AMPA/kainate receptor agonist in vitro: The (S)- but not (R)-isomers of willardiine and 5-bromowillardiine were potent agonists, producing rapidly but incompletely desensitizing responses . At a concentration of 1.8 mM, Ca2+ inhibited the currents induced by 100 microM willardiine by approximately 50% .in vivo: In newborn mice (P5, histopathology at P10), local injection of the AMPA receptor agonist S-bromo-willardiine at day 5 after birth induced cortical damage and white matter damage, which was reduced in a dose-dependent manner by the AMPA receptor antagonists .

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Membrane Transporter/Ion Channel

iGluR

iGluR

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21416-43-3

199.16

C7H9N3O4

>98% (HPLC)

In Vitro:?DMSO 中的溶解度 : < 1 mg/mL (insoluble or slightly soluble)

N[C@@H](Cn1ccc(=O)[nH]c1=O)C(O)=O

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(-20℃)

With Ice Pack

≥ 2 years