(RS)-AMPA

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

(RS)-AMPA 是一种谷氨酸类似物。 (RS)-AMPA 是一种有效的选择性兴奋性神经递质 L-谷氨酸的激动剂。

(RS)-AMPA is a glutamate analog. (RS)-AMPA is an agonist of effective and selective excitatory neurotransmitter L-glutamic acid.(In Vitro):(RS)-AMPA causes an increase of the discharge rate of spontaneously firing neurones or sometimes evoked a short burst of action potentials in silent cells. (RS)-AMPA exerts its depolarizing effects by activating glutamate/quisqualate receptors without affecting NMDA receptors. (RS)-AMPA causes depolarizations of cultured rat spinal and brainstem neurones in a clearly dose-dependent manner. Application of (RS)-AMPA(10-5 M) produces only small depolarizations (3-7 mV), whereas at 10-4 M, the amplitudes of the depolarizations ranged from 4 to 33 mV.

(RS)-AMPA (10-3-10-4 M) causes depolarizations of cultured rat spinal and brainstem neurones. The depolarization by (RS)-AMPA is clearly dose-dependent, although there is a great variability of effects between individual neurones. Application of (RS)-AMPA at 10-5 M produces only small depolarizations (3-7 mV), whereas at 10-4 M, the amplitudes of the depolarizations ranged from 4 to 33 mV. (RS)-AMPA also causes an increase of the discharge rate of spontaneously firing neurones or sometimes evoked a short burst of action potentials in silent cells. (RS)-AMPA exerts its depolarizing effects by activating glutamate/quisqualate receptors without affecting NMDA receptors.

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(±)-AMPA

Membrane Transporter/Ion Channel

iGluR

GABAA

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77521-29-0

186.167

C7H10N2O4

>98% (HPLC)

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Cc1o[nH]c(=O)c1CC(N)C(O)=O

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(-20℃)

With Ice Pack

≥ 2 years