(RS)-(Tetrazol-5-yl)glycine

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

(RS)-(Tetrazol-5-yl)glycine (D,L-(tetrazol-5-yl)glycine) 是一种有效的选择性 N-甲基-D-天冬氨酸受体激动剂。

(RS)-(Tetrazol-5-yl)glycine (D,L-(tetrazol-5-yl)glycine) is an effective and selective N-methyl-D-aspartate receptor agonist. (RS)-(Tetrazol-5-yl)glycine has EC50s of 99 nM, 1.7 μM for GluN1/GluN2D, and GluN1/GluN2A, respectively.(In Vitro):(RS)-(Tetrazol-5-yl)glycine does not appreciably inhibit the binding of D,L-alpha-[5-methyl-3H] amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA), [3H]kainate, or [3H]glycine (IC50s>30 μM). (RS)-(Tetrazol-5-yl)glycine displaces NMDA receptor binding to rat brain membranes as measured using [3H]CGS19755 (IC50=98 nM) and [3H]glutamate (IC50=36 nM) as ligands . (In Vivo):(RS)-(Tetrazol-5-yl)glycine is a potent convulsant when given to neonatal rats (ED50=0.071 mg/kg; i.p.). (RS)-(Tetrazol-5-yl)glycine (D,L-(tetrazol-5-yl)glycine; 1.25, 1.5 mg/kg; IP) causes seizure responses and Fos in the NR1+/+ and NR1-/- mice .

(RS)-(Tetrazol-5-yl)glycine (D,L-(tetrazol-5-yl)glycine) is a agonist of N-methyl-D-aspartate (NMDA) subtype of excitatory amino acid receptor. (RS)-(Tetrazol-5-yl)glycine displaces NMDA receptor binding to rat brain membranes as measured using [3H]CGS19755 (IC50=98 nM) and [3H]glutamate (IC50=36 nM) as ligands. (RS)-(Tetrazol-5-yl)glycine does not appreciably inhibit the binding of D,L-alpha-[5-methyl-3H] amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA), [3H]kainate, or [3H]glycine (IC50s>30 μM).

Animal Model:C57BL/6 mice Dosage:1.25, 1.5 mg/kg Administration:IP Result:Induced seizure responses and Fos.

D,L-(tetrazol-5-yl)glycine | LY 285265

Membrane Transporter/Ion Channel

NMDAR

Neuropeptide W/B receptor 1

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138199-51-6

143.106

C3H5N5O2

>98% (HPLC)

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NC(C(O)=O)c1nnn[nH]1

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(-20℃)

With Ice Pack

≥ 2 years