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(E)-3-(3,4-dichlorophenyl)-N-(2-(4-(methylsulfonyl)piperazin-1-yl)-2-oxoethyl)acrylamide
CAS No. 2505001-62-5
(E)-3-(3,4-dichlorophenyl)-N-(2-(4-(methylsulfonyl)piperazin-1-yl)-2-oxoethyl)acrylamide ( —— )
产品货号. M28598 CAS No. 2505001-62-5
(E)-3-(3,4-二氯苯基)-N-(2-(4-(甲磺酰基)哌嗪-1-基)-2-氧代乙基)丙烯酰胺是一种化合物。
纯度: >98% (HPLC)
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规格 | 价格/人民币 | 库存 | 数量 |
5MG | ¥786 | 有现货 |
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10MG | ¥1320 | 有现货 |
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25MG | ¥2657 | 有现货 |
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50MG | ¥4277 | 有现货 |
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100MG | ¥6124 | 有现货 |
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500MG | ¥12393 | 有现货 |
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1G | 获取报价 | 有现货 |
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生物学信息
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产品名称(E)-3-(3,4-dichlorophenyl)-N-(2-(4-(methylsulfonyl)piperazin-1-yl)-2-oxoethyl)acrylamide
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注意事项本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
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产品简述(E)-3-(3,4-二氯苯基)-N-(2-(4-(甲磺酰基)哌嗪-1-基)-2-氧代乙基)丙烯酰胺是一种化合物。
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产品描述(E)-3-(3,4-dichlorophenyl)-N-(2-(4-(methylsulfonyl)piperazin-1-yl)-2-oxoethyl)acrylamide is a chemical compound.
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体外实验SR18662 (0-10 μM; 24-72 hours) significantly reduces growth and proliferation of CRC cells as compared to treatment with vehicle control, ML264 (HY-19994). It shows improved efficacy in reducing viability of multiple CRC cell lines.SR18662 (10 μM; 24-72 hours) shows a significant increase in the number of apoptotic cells at both early and late states in DLD-1 and HCT116 cells.SR18662 (1 μM; 72 hours) reduces the expression of cyclins (cyclins E, A2, and B1) and components of MAPK (p-Erk) and WNT signaling pathways (p-GSK3 β) in cells.Cell Viability Assay Cell Line:CRC cells Concentration:0-10 μM Incubation Time:24 hours, 48 hours, 72 hours Result:Induced anti-tumor activity in colorectal cancer cell lines.Apoptosis Analysis Cell Line:DLD-1 and HCT116 cells Concentration:10 μMIncubation Time:24 hours, 48 hours, 72 hours Result:Increased apoptosis of colorectal cancer cell lines.Western Blot Analysis Cell Line:DLD-1 and HCT116 cells Concentration:1 μM Incubation Time:72 hours Result:Reduced levels of cyclins E, A2, and B1??inhibits activity of MAPK, WNT/β-catenin signaling pathways and decreases the levels of cyclins.
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体内实验SR18662 (intraperitoneal injection; 5-10 mg/kg; daily or twice daily; 5 days injection, days break, and 5 days) significantly reduces the growth of tumors in a mouse xenograft model. Animal Model:Nude mice with DLD-1 cells Dosage:5 mg/kg; 10 mg/kg; 25 mg/kg Administration:Intraperitoneal injection; 5mg/kg daily, 5mg/kg twice a day,10 mg/kg daily, 10 mg/kg twice per day, 25mg/kg daily, and 25 mg/kg twice per day; 5 days of injections, 2 days break, and 5 days of injections Result:Caused a significant dose-dependent inhibition of xenograft growth in mice.
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同义词——
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通路Others
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靶点Other Targets
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受体α2-adrenoceptor
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研究领域——
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适应症——
化学信息
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CAS Number2505001-62-5
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分子量420.31
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分子式C16H19Cl2N3O4S
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纯度>98% (HPLC)
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溶解度In Vitro:?DMSO : 125 mg/mL (297.40 mM)
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SMILESCS(N(CC1)CCN1C(CNC(/C=C/c(cc1)cc(Cl)c1Cl)=O)=O)(=O)=O
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1.Karlsson BR, Forsman M, Roald OK, Heier MS, Steen PA. Azepexole, a potent alpha 2-agonist with anaesthetic effects, does not affect cerebral energy consumption in dogs given isoflurane. Eur J Anaesthesiol. 1993 Mar;10(2):119-24. PMID: 8096459.
产品手册
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