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首页- Products - Others - Other Targets - (E)-3-(3,4-dichlorophenyl)-N-(2-(4-(methylsulfonyl)piperazin-1-yl)-2-oxoethyl)acrylamide

(E)-3-(3,4-dichlorophenyl)-N-(2-(4-(methylsulfonyl)piperazin-1-yl)-2-oxoethyl)acrylamide

CAS No. 2505001-62-5

(E)-3-(3,4-dichlorophenyl)-N-(2-(4-(methylsulfonyl)piperazin-1-yl)-2-oxoethyl)acrylamide ( —— )

产品货号. M28598 CAS No. 2505001-62-5

(E)-3-(3,4-二氯苯基)-N-(2-(4-(甲磺酰基)哌嗪-1-基)-2-氧代乙基)丙烯酰胺是一种化合物。

纯度: >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
规格 价格/人民币 库存 数量
5MG ¥786 有现货
10MG ¥1320 有现货
25MG ¥2657 有现货
50MG ¥4277 有现货
100MG ¥6124 有现货
500MG ¥12393 有现货
1G 获取报价 有现货

生物学信息

  • 产品名称
    (E)-3-(3,4-dichlorophenyl)-N-(2-(4-(methylsulfonyl)piperazin-1-yl)-2-oxoethyl)acrylamide
  • 注意事项
    本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
  • 产品简述
    (E)-3-(3,4-二氯苯基)-N-(2-(4-(甲磺酰基)哌嗪-1-基)-2-氧代乙基)丙烯酰胺是一种化合物。
  • 产品描述
    (E)-3-(3,4-dichlorophenyl)-N-(2-(4-(methylsulfonyl)piperazin-1-yl)-2-oxoethyl)acrylamide is a chemical compound.
  • 体外实验
    SR18662 (0-10 μM; 24-72 hours) significantly reduces growth and proliferation of CRC cells as compared to treatment with vehicle control, ML264 (HY-19994). It shows improved efficacy in reducing viability of multiple CRC cell lines.SR18662 (10 μM; 24-72 hours) shows a significant increase in the number of apoptotic cells at both early and late states in DLD-1 and HCT116 cells.SR18662 (1 μM; 72 hours) reduces the expression of cyclins (cyclins E, A2, and B1) and components of MAPK (p-Erk) and WNT signaling pathways (p-GSK3 β) in cells.Cell Viability Assay Cell Line:CRC cells Concentration:0-10 μM Incubation Time:24 hours, 48 hours, 72 hours Result:Induced anti-tumor activity in colorectal cancer cell lines.Apoptosis Analysis Cell Line:DLD-1 and HCT116 cells Concentration:10 μMIncubation Time:24 hours, 48 hours, 72 hours Result:Increased apoptosis of colorectal cancer cell lines.Western Blot Analysis Cell Line:DLD-1 and HCT116 cells Concentration:1 μM Incubation Time:72 hours Result:Reduced levels of cyclins E, A2, and B1??inhibits activity of MAPK, WNT/β-catenin signaling pathways and decreases the levels of cyclins.
  • 体内实验
    SR18662 (intraperitoneal injection; 5-10 mg/kg; daily or twice daily; 5 days injection, days break, and 5 days) significantly reduces the growth of tumors in a mouse xenograft model. Animal Model:Nude mice with DLD-1 cells Dosage:5 mg/kg; 10 mg/kg; 25 mg/kg Administration:Intraperitoneal injection; 5mg/kg daily, 5mg/kg twice a day,10 mg/kg daily, 10 mg/kg twice per day, 25mg/kg daily, and 25 mg/kg twice per day; 5 days of injections, 2 days break, and 5 days of injections Result:Caused a significant dose-dependent inhibition of xenograft growth in mice.
  • 同义词
    ——
  • 通路
    Others
  • 靶点
    Other Targets
  • 受体
    α2-adrenoceptor
  • 研究领域
    ——
  • 适应症
    ——

化学信息

  • CAS Number
    2505001-62-5
  • 分子量
    420.31
  • 分子式
    C16H19Cl2N3O4S
  • 纯度
    >98% (HPLC)
  • 溶解度
    In Vitro:?DMSO : 125 mg/mL (297.40 mM)
  • SMILES
    CS(N(CC1)CCN1C(CNC(/C=C/c(cc1)cc(Cl)c1Cl)=O)=O)(=O)=O
  • 化学全称
    ——

运输与储存

  • 储存条件
    (-20℃)
  • 运输条件
    With Ice Pack
  • 稳定性
    ≥ 2 years

参考文献

1.Karlsson BR, Forsman M, Roald OK, Heier MS, Steen PA. Azepexole, a potent alpha 2-agonist with anaesthetic effects, does not affect cerebral energy consumption in dogs given isoflurane. Eur J Anaesthesiol. 1993 Mar;10(2):119-24. PMID: 8096459.
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