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ZM-447439
CAS No. 331771-20-1
ZM-447439 ( ZM447439 | ZM 447439 )
产品货号. M14113 CAS No. 331771-20-1
ZM-447439 是一种有效的、选择性的 Aurora A 和 Aurora B 双重抑制剂，IC50 分别为 110 和 130 nM。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 5MG | ￥365 | 有现货 |
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| 10MG | ￥494 | 有现货 |
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| 50MG | ￥1742 | 有现货 |
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| 100MG | ￥2989 | 有现货 |
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| 200MG | 获取报价 | 有现货 |
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| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称ZM-447439
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述ZM-447439 是一种有效的、选择性的 Aurora A 和 Aurora B 双重抑制剂，IC50 分别为 110 和 130 nM。
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产品描述ZM-447439 is a potent, selective dual Aurora A and Aurora B inhibitor with IC50 of 110 and 130 nM, respectively; prevents anaplastic thyroid cancer cell growth and tumorigenicity, inhibits the growth and tumorigenicity of a panel of ATC derived cell lines (CAL-62, 8305C, 8505C and BHT-101) with IC50 of 0.5-5 uM; ZM447439-treated cells exit mitosis with normal kinetics, accelerates first meiosis in mouse oocytes by overriding the spindle assembly checkpoint.Blood Cancer Discontinued.
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体外实验Cells treated with ZM-447439 progress through interphase, enter mitosis normally, and assemble bipolar spindles. However, chromosome alignment, segregation, and cytokinesis all fail. ZM-447439 inhibits cell division and inhibit mitotic phosphorylation of histone H3. ZM-447439 prevents chromosome alignment and segregation. ZM-447439 compromises spindle checkpoint function. ZM-447439 inhibits kinetochore localization of BubR1, Mad2, and Cenp-E. Inhibition of Aurora kinase by ZM-447439 reduces histone H3 phosphorylation at Ser10 in Hep2 carcinoma cells. Multipolar spindles are induced in these ZM-treated G2/M-arrested cells with accumulation of 4N/8N DNA, similar to cells with genetically suppressed Aurora-B. ZM-447439 treatment induces cell apoptosis. ZM-447439 inhibition of Aurora kinase is potently in association with decrease of Akt phosphorylation at Ser473 and its substrates GSK3α/β phosphorylation at Ser21 and Ser9.
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体内实验——
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同义词ZM447439 | ZM 447439
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通路Cell Cycle/DNA Damage
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靶点Aurora Kinase
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受体Aurora A| Aurora B| MEK1| Lck| Src
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研究领域Cancer
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适应症Blood cancer
化学信息
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CAS Number331771-20-1
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分子量513.5875
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分子式C29H31N5O4
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纯度>98% (HPLC)
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溶解度10 mM in DMSO
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SMILESO=C(NC1=CC=C(NC2=C3C=C(OC)C(OCCCN4CCOCC4)=CC3=NC=N2)C=C1)C5=CC=CC=C5
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化学全称Benzamide, N-[4-[[6-methoxy-7-[3-(4-morpholinyl)propoxy]-4-quinazolinyl]amino]phenyl]-
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Baldini E, et al. J Biol Regul Homeost Agents. 2013 Jul-Sep;27(3):705-15.
2. Gadea BB, et al. Mol Biol Cell. 2005 Mar;16(3):1305-18.
3. Ditchfield C, et al. J Cell Biol. 2003 Apr 28;161(2):267-80.
4. Lane SI, et al. Reproduction. 2010 Oct;140(4):521-30.
产品手册
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