ZINC69391
CAS No. 303094-67-9
ZINC69391 ( ZINC-69391; N'-(4,6-dimethylpyrimidin-2-yl)-N-[2-(trifluoromethyl)phenyl]guanidine )
产品货号. M27796 CAS No. 303094-67-9
ZINC69391 is a selective inhibitor of Rac1 with antiproliferative and antimetastatic effects. ZINC69391 interferes with the interaction of Rac1 with Dock180, reduces Rac1-GTP levels and induces apoptosis.
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
规格 | 价格/人民币 | 库存 | 数量 |
5MG | ¥1725 | 有现货 |
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10MG | ¥2811 | 有现货 |
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25MG | ¥4771 | 有现货 |
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50MG | ¥6820 | 有现货 |
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100MG | ¥9396 | 有现货 |
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500MG | ¥18873 | 有现货 |
|
1G | 获取报价 | 有现货 |
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生物学信息
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产品名称ZINC69391
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注意事项本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
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产品简述ZINC69391 is a selective inhibitor of Rac1 with antiproliferative and antimetastatic effects. ZINC69391 interferes with the interaction of Rac1 with Dock180, reduces Rac1-GTP levels and induces apoptosis.
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产品描述ZINC69391 is a selective inhibitor of Rac1 with antiproliferative and antimetastatic effects. ZINC69391 interferes with the interaction of Rac1 with Dock180, reduces Rac1-GTP levels and induces apoptosis.(In Vitro):In U-87 MG and LN229 cells, ZINC69391 (0-125 μM) reduces cell proliferation of human glioma cells. ZINC69391 (50-100 μM) triggers cell cycle arrest. ZINC69391 inhibits the growth of U937, HL-60, KG1A, and Jurkat cells (IC50s = 41-54 μM). In HL-60, U937, and KG1A cell lines, ZINC69391 (50 μM) triggers an increase in apoptotic cells. In LN229 cells, ZINC69391 (50 and 100 μM) augments the enzymatic activity of caspase 3 and increases the percentage of cells in the sub-G0/G1 phase in a concentration-dependent manner.(In Vivo):In specific pathogen-free female BALB/c inbred mice (bearing F3II cells), ZINC69391 (25 mg/kg; i.p) impairs metastatic lung colonization and reduces by about 60% the formation of total metastatic lung colonies.
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同义词ZINC-69391; N'-(4,6-dimethylpyrimidin-2-yl)-N-[2-(trifluoromethyl)phenyl]guanidine
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通路Apoptosis
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靶点Apoptosis
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受体EGFR;EGFR (L858R);EGFR (L858R/T790M);EGFR (L858R/T790M/C797S)
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研究领域——
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适应症——
化学信息
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CAS Number303094-67-9
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分子量309.3
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分子式C14H14F3N5
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纯度>98% (HPLC)
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溶解度——
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SMILESCc1cc(C)nc(NC(=N)Nc2ccccc2C(F)(F)F)n1
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1.Zhang H, et al. Discovery of 2,4,6-trisubstitued pyrido[3,4-d]pyrimidine derivatives as new EGFR-TKIs. Eur J Med Chem. 2018 Mar 25;148:221-237.
产品手册
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