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YUM70
CAS No. 423145-35-1
YUM70 ( —— )
产品货号. M24387 CAS No. 423145-35-1
YUM70 是一种有效的选择性葡萄糖调节蛋白 78 (GRP78) 抑制剂（抑制全长蛋白 GRP78 ATPase 活性的 IC50 为 1.5 μM）。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 5MG | ￥1191 | 有现货 |
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| 10MG | ￥1847 | 有现货 |
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| 25MG | ￥3750 | 有现货 |
|
| 50MG | ￥5532 | 有现货 |
|
| 100MG | ￥7881 | 有现货 |
|
| 200MG | 获取报价 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称YUM70
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述YUM70 是一种有效的选择性葡萄糖调节蛋白 78 (GRP78) 抑制剂（抑制全长蛋白 GRP78 ATPase 活性的 IC50 为 1.5 μM）。
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产品描述YUM70 is a potent and selective glucose-regulated protein 78 (GRP78) inhibitor(with an IC50 of 1.5 μM for inhibiting GRP78 ATPase activity of the full-length protein).?It induces endoplasmic reticulum (ER) stress-mediated apoptosis in pancreatic cancer.?
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体外实验Western Blot Analysis Cell Line:MIA PaCa-2, PANC-1 cells Concentration:0.1, 1, 2.5, 5, 10 μM Incubation Time:2, 4, 8, 24, 48 hours Result:Increased the protein levels of FAM129A, DDIT3, CHAC-1, DDIT4, UPP1, and GRP78 in a dose- and time-dependent manner.
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体内实验Animal Model:8-week old female NCr nude mice were injected with MIA PaCa-2 cells Dosage:30 mg/kg Administration:I.p. 5 days a week for 7 weeks Result:Observed a significant tumor growth delay with no significant change in body weight during the course of treatment.
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同义词——
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通路Cell Cycle/DNA Damage
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靶点GPR
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受体GRP78
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研究领域——
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适应症——
化学信息
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CAS Number423145-35-1
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分子量398.84
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分子式C21H19ClN2O4
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纯度>98% (HPLC)
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溶解度DMSO:100 mg/mL?(250.73 mM;?Need ultrasonic)
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SMILESO=C(CCC)NC(C1=CC=C2C(OCO2)=C1)C(C=C(Cl)C3=C4N=CC=C3)=C4O
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1.Samanta S, et, al. The hydroxyquinoline analog YUM70 inhibits GRP78 to induce ER stress-mediated apoptosis in pancreatic cancer. Cancer Res. 2021 Feb 2;canres.1540.2020.
产品手册
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