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Teglicar

CAS No. 250694-07-6

Teglicar ( ST-1326;ST1326 )

产品货号. M13738 CAS No. 250694-07-6

Teglicar (ST-1326) is a potent, selective and reversible inhibitor of liver carnitine palmitoyl-transferase 1 (L-CPT1) with IC50 of 0.68 uM, Ki of 0.36 uM.

纯度: >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
规格 价格/人民币 库存 数量
5MG ¥3694 有现货
50MG ¥13851 有现货
100MG ¥20250 有现货
200MG 获取报价 有现货
500MG 获取报价 有现货
1G 获取报价 有现货

生物学信息

  • 产品名称
    Teglicar
  • 注意事项
    本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
  • 产品简述
    Teglicar (ST-1326) is a potent, selective and reversible inhibitor of liver carnitine palmitoyl-transferase 1 (L-CPT1) with IC50 of 0.68 uM, Ki of 0.36 uM.
  • 产品描述
    Teglicar (ST-1326) is a potent, selective and reversible inhibitor of liver carnitine palmitoyl-transferase 1 (L-CPT1) with IC50 of 0.68 uM, Ki of 0.36 uM; displays an extraordinarily high selectivity (39-fold) toward the liver isoform over the heart isoform (muscle-CPT1;M-CPT1); reduces gluconeogenesis and improves glucose homeostasis, shows antiketotic and antidiabetic activity in diabetic db/db mice; also inhibits fatty acid oxidation associated with cell growth arrest, mitochondrial damage, and apoptosis induction in leukemia cell lines; orally active.Diabetes Phase 2 Discontinued
  • 同义词
    ST-1326;ST1326
  • 通路
    Others
  • 靶点
    Other Targets
  • 受体
    Other Targets
  • 研究领域
    Metabolic Disease
  • 适应症
    Diabetes

化学信息

  • CAS Number
    250694-07-6
  • 分子量
    399.62
  • 分子式
    C22H45N3O3
  • 纯度
    >98% (HPLC)
  • 溶解度
    ——
  • SMILES
    CCCCCCCCCCCCCCNC(=O)NC(CC(=O)[O-])C[N+](C)(C)C
  • 化学全称
    (R)-4-Trimethylammonio-3-[(tetradecylcarbamoyl)amino]butyrate

运输与储存

  • 储存条件
    (-20℃)
  • 运输条件
    With Ice Pack
  • 稳定性
    ≥ 2 years

参考文献

1. Ricciardi MR, et al. Blood. 2015 Oct 15;126(16):1925-9.
2. Giannessi F, et al. J Med Chem. 2003 Jan 16;46(2):303-9.
3. Conti R, et al. Diabetes. 2011 Feb;60(2):644-51.
产品手册
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