Teglicar
CAS No. 250694-07-6
Teglicar ( ST-1326;ST1326 )
产品货号. M13738 CAS No. 250694-07-6
Teglicar (ST-1326) is a potent, selective and reversible inhibitor of liver carnitine palmitoyl-transferase 1 (L-CPT1) with IC50 of 0.68 uM, Ki of 0.36 uM.
纯度: >98% (HPLC)
规格 | 价格/人民币 | 库存 | 数量 |
5MG | ¥3694 | 有现货 |
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50MG | ¥13851 | 有现货 |
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100MG | ¥20250 | 有现货 |
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200MG | 获取报价 | 有现货 |
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500MG | 获取报价 | 有现货 |
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1G | 获取报价 | 有现货 |
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生物学信息
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产品名称Teglicar
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注意事项本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
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产品简述Teglicar (ST-1326) is a potent, selective and reversible inhibitor of liver carnitine palmitoyl-transferase 1 (L-CPT1) with IC50 of 0.68 uM, Ki of 0.36 uM.
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产品描述Teglicar (ST-1326) is a potent, selective and reversible inhibitor of liver carnitine palmitoyl-transferase 1 (L-CPT1) with IC50 of 0.68 uM, Ki of 0.36 uM; displays an extraordinarily high selectivity (39-fold) toward the liver isoform over the heart isoform (muscle-CPT1;M-CPT1); reduces gluconeogenesis and improves glucose homeostasis, shows antiketotic and antidiabetic activity in diabetic db/db mice; also inhibits fatty acid oxidation associated with cell growth arrest, mitochondrial damage, and apoptosis induction in leukemia cell lines; orally active.Diabetes Phase 2 Discontinued
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同义词ST-1326;ST1326
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通路Others
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靶点Other Targets
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受体Other Targets
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研究领域Metabolic Disease
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适应症Diabetes
化学信息
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CAS Number250694-07-6
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分子量399.62
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分子式C22H45N3O3
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纯度>98% (HPLC)
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溶解度——
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SMILESCCCCCCCCCCCCCCNC(=O)NC(CC(=O)[O-])C[N+](C)(C)C
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化学全称(R)-4-Trimethylammonio-3-[(tetradecylcarbamoyl)amino]butyrate
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
2. Giannessi F, et al. J Med Chem. 2003 Jan 16;46(2):303-9.
3. Conti R, et al. Diabetes. 2011 Feb;60(2):644-51.
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