SP-96

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

SP-96 是一种高效、选择性的 Aurora B 抑制剂，IC50 为 0.316 nM。 SP-96 在 NCI60 筛选中显示出选择性生长抑制，包括 MDA-MD-468 (GI50=107 nM)。 SP-96 可用于三阴性乳腺癌研究。

SP-96 is a highly effective and selective inhibitor of Aurora B with an IC50 of 0.316 nM. SP-96 shows selective growth inhibition in NCI60 screening, including MDA-MD-468 (GI50=107 nM). SP-96 can be used in triple negative breast cancer studies.(In Vitro):SP-96 (63.2 nM) inhibits Aurora B activity in H460 cells by the characteristics of increased DNA content, and it increases cell volume with enormous nucleus. SP-96 shows >2000 fold selectivity against FLT3 (IC50=1475.6 nM) and KIT (IC50=1307.6 nM). SP-96 (0-2 μM) inhibits Aurora A with IC50 value of 18.975 nM. SP-96 (0-1 μM; 24 hours) is not promiscuous, rather selective for a few cell lines, it inhibits MDA-MB-468, CCRF-CEM, COLO 205 and A498 cell growth with GI50 values of 107 nM,47.4 nM, 50.3 nM and 53.2 nM, respectively.

Cell Viability Assay Cell Line:MDA-MB-468, CCRF-CEM, COLO 205 and A498 cell Concentration:0-1 μM Incubation Time:24 hours Result:Showed good inhibitory activity on MDA-MB-468 cells.

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Cell Cycle/DNA Damage

Aurora Kinase

β-adrenergic receptor

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2682114-54-9

453.47

C25H20FN7O

>98% (HPLC)

In Vitro:?DMSO : 100 mg/mL (220.52 mM)

Cn1ncc(-c2ccc3c(Nc4cccc(NC(Nc5cccc(F)c5)=O)c4)ncnc3c2)c1

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(-20℃)

With Ice Pack

≥ 2 years