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SB-743921
CAS No. 940929-33-9
SB-743921 ( SB743921;SB 743921 )
产品货号. M16731 CAS No. 940929-33-9
SB-743921 is a potent, selective kinesin spindle protein (KSP) inhibitor with Ki of 0.1 nM.
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 2MG | ￥518 | 有现货 |
|
| 5MG | ￥818 | 有现货 |
|
| 10MG | ￥1377 | 有现货 |
|
| 25MG | ￥2406 | 有现货 |
|
| 50MG | ￥4261 | 有现货 |
|
| 100MG | ￥6148 | 有现货 |
|
| 500MG | ￥12798 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称SB-743921
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述SB-743921 is a potent, selective kinesin spindle protein (KSP) inhibitor with Ki of 0.1 nM.
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产品描述SB-743921 is a potent, selective kinesin spindle protein (KSP) inhibitor with Ki of 0.1 nM, shows no activity against MKLP1, Kin2, Kif1A, Kif15, KHC, Kif4 and CENP-E; also shows high affinity for mouse KSP with Ki of 0.12 nM; blocks assembly of a functional mitotic spindle, thereby causing cell cycle arrest in mitosis and subsequent cell death in cancer cells, demonstrates improved potency over ispinesib in both biochemical and cellular assays; shows a broad spectrum of tumor inhibition in multiple cancer models.Blood Cancer Phase 2 Discontinued
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同义词SB743921;SB 743921
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通路Cytoskeleton/Cell Adhesion Molecules
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靶点Kinesin
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受体KSP;KSP(Colo205cells);KSP(MV522cells);KSP(MX1cells);KSP(SKOV3cells)
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研究领域Cancer
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适应症Blood cancer
化学信息
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CAS Number940929-33-9
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分子量553.52
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分子式C31H34Cl2N2O3
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纯度>98% (HPLC)
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溶解度10 mM in DMSO
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SMILESCC1=CC=C(C=C1)C(=O)N(CCCN)C(C2=C(C(=O)C3=C(O2)C=C(C=C3)Cl)CC4=CC=CC=C4)C(C)C.Cl
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化学全称Benzamide, N-(3-aminopropyl)-N-[(1R)-1-[7-chloro-4-oxo-3-(phenylmethyl)-4H-1-benzopyran-2-yl]-2-methylpropyl]-4-methyl-, hydrochloride (1:1)
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Good JA, et al. J Med Chem. 2013 Mar 14;56(5):1878-93.
2. Holen KD, et al. Cancer Chemother Pharmacol. 2011 Feb;67(2):447-54.
3. Zhu L, et al. Anticancer Drugs. 2016 Oct;27(9):863-72.
4. Talapatra SK, et al. J Med Chem. 2013 Aug 22;56(16):6317-29.
2. Holen KD, et al. Cancer Chemother Pharmacol. 2011 Feb;67(2):447-54.
3. Zhu L, et al. Anticancer Drugs. 2016 Oct;27(9):863-72.
4. Talapatra SK, et al. J Med Chem. 2013 Aug 22;56(16):6317-29.
产品手册
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