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Rg3039
CAS No. 1005504-62-0
Rg3039 ( RG3039 | RG 3039 | PF 06687859 | PF-06687859 )
产品货号. M17746 CAS No. 1005504-62-0
RG3039 (PF-06687859) 是一种有效的 DcpS 抑制剂。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 2MG | ￥259 | 有现货 |
|
| 5MG | ￥413 | 有现货 |
|
| 10MG | ￥680 | 有现货 |
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| 25MG | ￥1337 | 有现货 |
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| 50MG | ￥2203 | 有现货 |
|
| 100MG | ￥3548 | 有现货 |
|
| 500MG | ￥7979 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称Rg3039
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述RG3039 (PF-06687859) 是一种有效的 DcpS 抑制剂。
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产品描述RG3039, also known as PF-06687859, is a potent DcpS inhibitor. DcpS is a therapeutic target for spinal muscular atrophy. Spinal muscular atrophy (SMA) is caused by deletion or mutation of both copies of the SMN1 gene which produces an essential protein known as SMN. RG3039 improves motor function in SMA mice. RG3039 also showed activity to improve survival, function and motor unit pathologies in two SMA mouse models.
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体外实验——
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体内实验——
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同义词RG3039 | RG 3039 | PF 06687859 | PF-06687859
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通路Cell Cycle/DNA Damage
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靶点GPR
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受体DcpS
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研究领域——
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适应症——
化学信息
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CAS Number1005504-62-0
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分子量432.35
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分子式C21H23Cl2N5O
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纯度>98% (HPLC)
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溶解度DMSO : 6 mg/mL 13.88 mM; H2O : < 0.1 mg/mL
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SMILESC1CN(CCC1COc1cccc2c1c(nc(n2)N)N)Cc1c(cccc1Cl)Cl
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化学全称5-((1-(2,6-dichlorobenzyl)piperidin-4-yl)methoxy)quinazoline-2,4-diamine
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Rocky G. Gogliotti, et al. Hum Mol Genet. 2013 Oct 15; 22(20): 4084–4101.
