021-51111890
购物车（）
sales@molnova.cn
Mirin
CAS No. 1198097-97-0
Mirin ( Mirin )
产品货号. M10709 CAS No. 1198097-97-0
A small molecule inhibitor of MRN (Mre11-Rad50-Nbs1) pathway that inhibits Mre11-associated exonuclease activity.
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 5MG | ￥405 | 有现货 |
|
| 10MG | ￥640 | 有现货 |
|
| 25MG | ￥1158 | 有现货 |
|
| 50MG | ￥1928 | 有现货 |
|
| 100MG | ￥3548 | 有现货 |
|
| 200MG | ￥4625 | 有现货 |
|
| 500MG | ￥7428 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
-
产品名称Mirin
-
注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
-
产品简述A small molecule inhibitor of MRN (Mre11-Rad50-Nbs1) pathway that inhibits Mre11-associated exonuclease activity.
-
产品描述A small molecule inhibitor of MRN (Mre11-Rad50-Nbs1) pathway that inhibits Mre11-associated exonuclease activity; prevents MRN-dependent activation of ATM (IC50=12 uM) without affecting ATM protein kinase activity; inhibits Mre11 nuclease activity at 100 uM, does not inhibit ExoIII nuclease activity; inhibits the G2 checkpoint, and blocks homology-directed repair (HDR) in mammalian cells.
-
同义词Mirin
-
通路Others
-
靶点Other Targets
-
受体MRN
-
研究领域Cancer
-
适应症——
化学信息
-
CAS Number1198097-97-0
-
分子量220.25
-
分子式C10H8N2O2S
-
纯度>98% (HPLC)
-
溶解度DMSO: ≥ 31 mg/mL
-
SMILESO=C1NC(S/C1=C\C2=CC=C(O)C=C2)=N
-
化学全称4(5H)-Thiazolone, 2-amino-5-[(4-hydroxyphenyl)methylene]-, (5Z)-
运输与储存
-
储存条件(-20℃)
-
运输条件With Ice Pack
-
稳定性≥ 2 years
参考文献
1. Dupré A, et al. Nat Chem Biol. 2008 Feb;4(2):119-25.
2. Lee JH, et al. J Biol Chem. 2013 May 3;288(18):12840-51.
3. Rozier L, et al. Mol Cell. 2013 Mar 28;49(6):1097-107.
2. Lee JH, et al. J Biol Chem. 2013 May 3;288(18):12840-51.
3. Rozier L, et al. Mol Cell. 2013 Mar 28;49(6):1097-107.
产品手册
关联产品
-
4-Amino-5-Chloro-2-M...
Used as organic synthesis and medicine intermediate.
-
6-methyl-2-[2-[(E)-(...
6-methyl-2-[2-[(E)-(6-oxo-1-cyclohexa-2,4-dienylidene)methyl]hydraziny l]-1H-pyrimidin-4-one.
-
Thalidomide-O-amido-...
Thalidomide-O-amido-C6-NH2 TFA, a synthesized E3 ligase ligand-linker conjugate containing a Thalidomide-based cereblon ligand and a linker.
