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Mirin

CAS No. 1198097-97-0

Mirin ( Mirin )

产品货号. M10709 CAS No. 1198097-97-0

A small molecule inhibitor of MRN (Mre11-Rad50-Nbs1) pathway that inhibits Mre11-associated exonuclease activity.

纯度: >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
规格 价格/人民币 库存 数量
5MG ¥405 有现货
10MG ¥640 有现货
25MG ¥1158 有现货
50MG ¥1928 有现货
100MG ¥3548 有现货
200MG ¥4625 有现货
500MG ¥7428 有现货
1G 获取报价 有现货

生物学信息

  • 产品名称
    Mirin
  • 注意事项
    本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
  • 产品简述
    A small molecule inhibitor of MRN (Mre11-Rad50-Nbs1) pathway that inhibits Mre11-associated exonuclease activity.
  • 产品描述
    A small molecule inhibitor of MRN (Mre11-Rad50-Nbs1) pathway that inhibits Mre11-associated exonuclease activity; prevents MRN-dependent activation of ATM (IC50=12 uM) without affecting ATM protein kinase activity; inhibits Mre11 nuclease activity at 100 uM, does not inhibit ExoIII nuclease activity; inhibits the G2 checkpoint, and blocks homology-directed repair (HDR) in mammalian cells.
  • 同义词
    Mirin
  • 通路
    Others
  • 靶点
    Other Targets
  • 受体
    MRN
  • 研究领域
    Cancer
  • 适应症
    ——

化学信息

  • CAS Number
    1198097-97-0
  • 分子量
    220.25
  • 分子式
    C10H8N2O2S
  • 纯度
    >98% (HPLC)
  • 溶解度
    DMSO: ≥ 31 mg/mL
  • SMILES
    O=C1NC(S/C1=C\C2=CC=C(O)C=C2)=N
  • 化学全称
    4(5H)-Thiazolone, 2-amino-5-[(4-hydroxyphenyl)methylene]-, (5Z)-

运输与储存

  • 储存条件
    (-20℃)
  • 运输条件
    With Ice Pack
  • 稳定性
    ≥ 2 years

参考文献

1. Dupré A, et al. Nat Chem Biol. 2008 Feb;4(2):119-25.
2. Lee JH, et al. J Biol Chem. 2013 May 3;288(18):12840-51.
3. Rozier L, et al. Mol Cell. 2013 Mar 28;49(6):1097-107.
产品手册
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