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MA-0204
CAS No. 2095128-17-7
MA-0204 ( —— )
产品货号. M23943 CAS No. 2095128-17-7
MA-0204 是一种高选择性、口服的过氧化物酶体增殖物激活受体 δ (PPARδ) 调节剂。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 5MG | ￥2535 | 有现货 |
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| 10MG | ￥4277 | 有现货 |
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| 25MG | ￥6958 | 有现货 |
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| 50MG | ￥9639 | 有现货 |
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| 100MG | ￥12798 | 有现货 |
|
| 200MG | 获取报价 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称MA-0204
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述MA-0204 是一种高选择性、口服的过氧化物酶体增殖物激活受体 δ (PPARδ) 调节剂。
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产品描述MA-0204 is a highly selective and orally available peroxisome proliferator-activated receptor δ (PPARδ) modulator (EC50s: 0.4 nM, 7.9 nM and 10 nM for human, mouse and rat PPARδ, respectively). It is a potential treatment for Duchene Muscular Dystrophy (DMD).
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体外实验MA-0204 is >10,000-fold selective for activation of PPARδ over PPARα and PPARγ receptors. MA-0204 exhibits high protein binding to mouse plasma, good permeability and low potential for efflux. C.MA-0204 (1.2-12 nM) improves fatty acid oxidation in DMD patient muscle myoblasts mice.MA-0204 (0.04-40 nM) engages target gene expression in DMD patient muscle myoblasts.
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体内实验PPARδ (30, 100 mg/kg) increases target gene transcription in the muscle.
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同义词——
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通路Metabolic Enzyme/Protease
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靶点PPAR
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受体PPARδ
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研究领域——
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适应症——
化学信息
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CAS Number2095128-17-7
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分子量476.49
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分子式C25H27F3N2O4
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纯度>98% (HPLC)
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溶解度DMSO:40 mg/mL (83.95 mM; Need ultrasonic)
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SMILESC[C@H](CCCOc1c(Cn2c(-c(cc3)ccc3OC(F)(F)F)ncc2C)cccc1)CC(O)=O
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1.Lagu B, et al. Selective PPARδ Modulators Improve Mitochondrial Function: Potential Treatment for Duchenne Muscular Dystrophy (DMD). ACS Med Chem Lett. 2018 Jul 31;9(9):935-940.
产品手册
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