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KYP-2047
CAS No. 796874-99-2
KYP-2047 ( —— )
产品货号. M22395 CAS No. 796874-99-2
KYP-2047 is a very potent, selective Prolyl oligopeptidase (POP) inhibitor.In cell lines, oxidative stress induced a robust aggregation of α-synuclein,and low concentrations of KYP-2047 significantly reduced the number of cells with α-synuclein inclusions while abolishing the colocalization of α-synuclein and PREP.
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 2MG | ￥753 | 有现货 |
|
| 5MG | ￥1077 | 有现货 |
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| 10MG | ￥1628 | 有现货 |
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| 25MG | ￥2940 | 有现货 |
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| 50MG | ￥4398 | 有现货 |
|
| 100MG | ￥6342 | 有现货 |
|
| 200MG | 获取报价 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称KYP-2047
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述KYP-2047 is a very potent, selective Prolyl oligopeptidase (POP) inhibitor.In cell lines, oxidative stress induced a robust aggregation of α-synuclein,and low concentrations of KYP-2047 significantly reduced the number of cells with α-synuclein inclusions while abolishing the colocalization of α-synuclein and PREP.
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产品描述KYP-2047 is a very potent, selective Prolyl oligopeptidase (POP) inhibitor.In cell lines, oxidative stress induced a robust aggregation of α-synuclein,and low concentrations of KYP-2047 significantly reduced the number of cells with α-synuclein inclusions while abolishing the colocalization of α-synuclein and PREP. KYP-2047 significantly reduced the amount of aggregated α-synuclein,and it had beneficial effects on cell viability.?In the transgenic mice, a 5-day treatment with the PREP inhibitor reduced the amount of α-synuclein immunoreactivity and soluble α-synuclein protein in the brain.
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同义词——
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通路Others
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靶点Other Targets
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受体Prolyl oligopeptidase(pop)
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研究领域——
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适应症——
化学信息
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CAS Number796874-99-2
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分子量339.44
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分子式C20H25N3O2
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纯度>98% (HPLC)
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溶解度——
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SMILESO=C(CCCc1ccccc1)N1CCC[C@H]1C(=O)N1CCC[C@H]1C#N
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. T T My?h?nen 1 , M J Hannula, R Van Elzen,et al.A prolyl oligopeptidase inhibitor, KYP-2047, reduces α-synuclein protein levels and aggregates in cellular and animal models of Parkinson's disease.Br J Pharmacol. 2012 Jun;166(3):1097-113.
产品手册
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