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KD-3010
CAS No. 934760-92-6
KD-3010 ( —— )
产品货号. M32979 CAS No. 934760-92-6
KD-3010 是一种具有口服活性的有效的选择性 PPARδ 激动剂。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 25MG | ￥14232 | 有现货 |
|
| 50MG | ￥18612 | 有现货 |
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| 100MG | ￥23715 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称KD-3010
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述KD-3010 是一种具有口服活性的有效的选择性 PPARδ 激动剂。
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产品描述KD-3010 is a potent, orally active, and selective PPARδ agonist.
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体外实验——
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体内实验To determine whether PPARδ agonists are beneficial in experimental liver fibrosis, mice are treated orally with a PPARδ agonist, KD-3010, or with the well-validated PPARδ agonist GW501516. KD-3010, but not GW501516, shows hepatoprotective and antifibrotic effects in liver fibrosis induced by carbon tetrachloride (CCl4) or bile duct ligation (BDL). Liver injury is induced by repeated injections of CCl4, and mice are treated daily with vehicle, the widely used PPARδ agonist GW501516, or the PPARδ agonist KD-3010 by oral gavage. Control oil-injected mice do not show any liver damage. Liver injury consisting of hepatocyte death and inflammation is seen in the vehicle- or GW501516-treated group injected with CCl4 on H&E-stained liver sections but is markedly reduced in the KD3010-treated group.
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同义词——
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通路Metabolic Enzyme/Protease
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靶点PPAR
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受体PPAR
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研究领域——
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适应症——
化学信息
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CAS Number934760-92-6
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分子量670.72
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分子式C30H33F3N2O8S2
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纯度>98% (HPLC)
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溶解度——
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SMILESS(=O)(=O)(O)C1=CC=C(C)C=C1.S(=O)(=O)(C1=C2C(C[C@H](C(O)=O)C2)=CC=C1)N3[C@H](C)CN(C[C@@H]3C)C4=CC=C(OC(F)(F)F)C=C4
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Iwaisako K, et al. Protection from liver fibrosis by a peroxisome proliferator-activated receptor δ agonist. Proc Natl Acad Sci U S A. 2012 May 22;109(21):E1369-76.?
