GW590735

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

GW590735 是一种有效的选择性 PPARα 激动剂，对 PPARα 的 EC50 为 4 nM，且选择性比 PPARδ 和 PPARγ 至少高 500 倍。 GW590735 可用于血脂异常研究。

GW590735 is an effective and selective PPARα agonist with an EC50 of 4 nM on PPARα and at least 500-fold selectivity versus PPARδ and PPARγ. GW590735 can be used in dyslipidemia studies.(In Vivo):GW590735 (2 mg/kg; i.v.) shows Cl, Vd, T1/2, and F% are 13 mL/min/kg, 2.8 L/kg, 2.6 hours and 85%, respectively in dogs while GW590735 (2.7 mg/kg; i.v.) shows Cl, Vd, T1/2, and F% are 5 mL/min/kg, 1 L/kg, 2.4 hours and 47%, respectively in rats. In male C57BL/6 mice transgenic for human ApoA-I, GW590735 (0.5-5 mg/kg; oral) is able to lower LDLc and triglycerides (TG) and increase HDL cholesterol.

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GW 590735 (0.5-5 mg/kg; orally twice a day for 5 days) is able to lower LDLc and triglycerides (TG) and increase HDL cholesterol in the Apo-A-I-transgenic mouse model (male C57BL/6 mice transgenic for human ApoA-I).GW 590735 (intravenous administration; 2.7 mg/kg; rat) treatment shows Cl, Vd, T1/2, and F% are 5 mL/min/kg, 1 L/kg, 2.4 hours and 47%, respectively.GW 590735 (intravenous administration; 2 mg/kg; dog) treatment shows Cl, Vd, T1/2, and F% are 13 mL/min/kg, 2.8 L/kg, 2.6 hours and 85%, respectively.

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Metabolic Enzyme/Protease

PPAR

norepinephrine|nAChR

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343321-96-0

478.48

C23H21F3N2O4S

>98% (HPLC)

In Vitro:?DMSO : 250 mg/mL (522.49 mM)

CC(C)(C(O)=O)Oc1ccc(CNC(c2c(C)nc(-c3ccc(C(F)(F)F)cc3)s2)=O)cc1

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(-20℃)

With Ice Pack

≥ 2 years