Daltroban

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Daltroban (BM-13505) 是一种选择性和特异性血栓素 A2 (TXA2) 受体拮抗剂。Daltroban 增加血管平滑肌细胞内钙。Daltroban 对再灌注损伤有保护作用。

Daltroban (BM-13505) is a selective and specific thromboxane A2 (TXA2) receptor antagonist. Daltroban increase intracellular calcium in vascular smooth muscle cells. Daltroban shows protective effect in reperfusion injury.

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Daltroban (BM-13505) (1 mg/kg; i.v.; per hour) exerts protective effect in reperfusion injury following acute myocardial ischemia in cats.In comparison with vehicle (physiological saline)-treated cats, Daltroban (20 mg/kg per hour i.v.) reduces the ischaemia-induced rise in the ST segment and prevented the development of a Q-wave in the ECG during reperfusion. Daltroban protects the myocardium from ischaemic injury and that this effect involves prevention of ischaemia-induced leukocytosis. Animal Model:Adult male cats (2.8 to 4.6 kg; anesthetized cat model)Dosage:1 mg/kg Administration: i.v.; 30 minutes before reperfusion at a rate of 1 mg/kg followed by 1 mg/kg/hour Result:Significantly reduced the area of ischemic tissue as a percent of total left ventricular mass and total area at risk, without altering basic hemodynamics and thereby not influencing myocardial oxygen demand.

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Metabolic Enzyme/Protease

PPAR

PPAR

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79094-20-5

353.82

C16H16ClNO4S

>98% (HPLC)

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OC(=O)Cc1ccc(CCNS(=O)(=O)c2ccc(Cl)cc2)cc1

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(-20℃)

With Ice Pack

≥ 2 years