Clofibrate

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Clofibrate (Atromid-S)，一种纤维酸衍生物，用于治疗 III 型高脂蛋白血症和严重高甘油三酯血症。

Clofibrate (Atromid-S), a fibric acid derivative used in the treatment of hyperlipoproteinemia type III and severe hypertriglyceridemia.(In Vitro):Clofibrate is a PPAR agonist, with E50s of 50 μM, ～500 μM for murine PPARα and PPARγ, and 55 μM, ～500 μM for human PPARα and PPARγ, respectively. Clofibrate (0.5, 1, 2 mM) increases FABP1 expression in two fatty acid (FA)-treated rat hepatoma cells. Clofibrate lowers ROS levels after early treatment, much more than late treatment in FA-treated cells.(In Vivo):Clofibrate (0.5%) up-regulates serum concentrations and hepatic expression of FGF21 in fetuses, with a return to basal levels after Clofibrate administration withdrawal. Clofibrate administration-offspring have significantly higher expression of thermogenic genes (Ucp1, Cidea, Ppara Ppargc1a, Cpt1b) and UCP1 protein levels in response to HFD in inguinal fat, but not in retroperitoneal (combined with perirenal) or epididymal fat.

Clofibrate is a PPAR agonist, with E50s of 50 μM, ～500 μM for murine PPARα and PPARγ, and 55 μM, ～500 μM for human PPARα and PPARγ, respectively. Clofibrate (0.5, 1, 2 mM) increases FABP1 expression in two fatty acid (FA)-treated rat hepatoma cells. Clofibrate lowers ROS levels after early treatment, much more than late treatment in FA-treated cells.

Clofibrate (0.5%) up-regulates serum concentrations and hepatic expression of FGF21 in fetuses, with a return to basal levels after Clofibrate administration withdrawal. Clofibrate administration-offspring have significantly higher expression of thermogenic genes (Ucp1, Cidea, Ppara Ppargc1a, Cpt1b) and UCP1 protein levels in response to HFD in inguinal fat, but not in retroperitoneal (combined with perirenal) or epididymal fat.

ICI 28257 | NSC 79389

Metabolic Enzyme/Protease

PPAR

PPARα

Cardiovascular Disease

——

637-07-0

242.7

C12H15ClO3

>98% (HPLC)

DMSO: 7 mg/mL; Water: <1 mg/mL

CCOC(=O)C(C)(C)OC1=CC=C(Cl)C=C1

——

(-20℃)

With Ice Pack

≥ 2 years