CUDA

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

CUDA 是一种有效的可溶性环水解酶抑制剂，对小鼠 sEH 和人 sEH 的 IC50 分别为 11.1 nM 和 112 nM。

CUDA is an effective soluble cyclohydrolase inhibitor with IC50 of 11.1 nM and 112 nM for mouse sEH and human sEH, respectively. CUDA selectively increases the activity of peroxisome proliferator-activated receptor (PPAR) alpha. CUDA may be valuable for the study of cardiovascular diseases.(In Vitro):CUDA (10 μM; 18 hours) produced a 6-fold and 3-fold increase of PPARalpha in COS-7 cells. CUDA does not change the expression of PPARalpha protein. It competitively inhibits the binding of Wy-14643 (pirinixic acid) to the ligand binding domain of PPARalpha, indicating that it acts as a PPARalpha ligand.

CUDA (10 μM; 18 hours) produces 6- and 3-fold increases of PPARalpha in COS-7 cells.CUDA does not alter PPARalpha protein expression, and it competitively inhibits the binding of Wy-14643 (pirinixic acid) to the ligand binding domain of PPARalpha, suggesting that it functions as a PPARalpha ligand. Western Blot Analysis Cell Line:COS-7 cells Concentration:10 μM Incubation Time:18 hours Result:Activated PPARα by binding to the ligand binding domain of PPARα.

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Metabolic Enzyme/Protease

PPAR

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479413-68-8

340.508

C19H36N2O3

>98% (HPLC)

In Vitro:?DMSO : 25 mg/mL (73.42 mM)

OC(=O)CCCCCCCCCCCNC(=O)NC1CCCCC1

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(-20℃)

With Ice Pack

≥ 2 years