BTB09089

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

BTB09089 是 T 细胞死亡相关基因 8 (TDAG8/GPR65) 特异性激动剂。BTB09089 增加 TDAG8 的表达，调节 T 细胞和巨噬细胞细胞因子的产生。

BTB09089 is a T cell death-associated gene 8 (TDAG8/GPR65) specific agonist. BTB09089 increases TDAG8 expression and regulates the cytokine production of T cells and macrophages.

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Animal Model:Adult male SD rats (270-280 g), middle cerebral artery occlusion (MCAO) model Dosage:5, 10 and 20 μM, 8 μL Administration:Intracerebroventricular injection, six hours prior to MCAO Result:Up-regulated TDAG8 and Bcl-2 expression and down-regulated cleaved caspase-3 expression, while the infarction volume was reduced, and neurological deficits were ameliorated 24 and 72 h after MCAO.

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Cell Cycle/DNA Damage

GPR

GPR | DNA

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245728-44-3

387.31

C14H12Cl2N4OS2

>98% (HPLC)

In Vitro:?DMSO 中的溶解度 : 100 mg/mL (258.19 mM; 超声助溶 (<80°C)

CN1C2=C(SC(SCC3=C(Cl)C=C(Cl)C=C3)=N1)C(=O)N(C)N=C2

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(-20℃)

With Ice Pack

≥ 2 years