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BPR1K653
CAS No. 1192754-06-5
BPR1K653 ( BPR1K 653 )
产品货号. M10668 CAS No. 1192754-06-5
BPR1K653 是一种新型强效 Aurora 激酶抑制剂，可抑制 Aurora-A 和 Aurora-B，IC50 分别为 24 nM 和 45 nM。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 100MG | 获取报价 | 有现货 |
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| 200MG | 获取报价 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称BPR1K653
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述BPR1K653 是一种新型强效 Aurora 激酶抑制剂，可抑制 Aurora-A 和 Aurora-B，IC50 分别为 24 nM 和 45 nM。
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产品描述BPR1K653 is a novel potent Aurora kinase inhibitor that inhibits Aurora-A and Aurora-B with IC50 of 24 nM and 45 nM, respectively; exhibits less potency (IC50>10 uM) in inhibiting the activity of ALK, CHK1, cMET, EGFR, FLT3, VEGFR1 and VEGFR2; induces concentration-dependent decrease in phosphor-Aurora-A, -B and -C kinase in HCT116 cells, inhibits the proliferation of multiple human cancer cell lines regardless of their tissue origins and p53 status (IC50s<0.5 uM); shows equal potency in inhibiting the growth of the multiple-drug resistance protein (MDR1) -expressing cancer cells; also is effective toward MDR1-expressing tumor xenograft.
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体外实验——
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体内实验——
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同义词BPR1K 653
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通路Cell Cycle/DNA Damage
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靶点Aurora Kinase
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受体Aurora Kinase
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研究领域——
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适应症——
化学信息
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CAS Number1192754-06-5
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分子量541.052
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分子式C30H29ClN6O2
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纯度>98% (HPLC)
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溶解度——
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SMILESO=C(NC1=CC=CC=C1CN(C)C)NC2=CC=C(CCNC3=C4C(OC(C5=CC=CC=C5)=C4Cl)=NC=N3)C=C2
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化学全称1-(4-(2-((5-chloro-6-phenylfuro[2,3-d]pyrimidin-4-yl)amino)ethyl)phenyl)-3-(2-((dimethylamino)methyl)phenyl)urea
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Cheung CH, et al. PLoS One. 2011;6(8):e23485.
