Ankaflavin

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Ankaflavin 是从红曲发酵红米中分离出来的，是一种具有抗炎活性的 PPARγ 激动剂。红卡黄素表现出选择性细胞毒性作用并诱导癌细胞死亡。

Ankaflavin, isolated from Monascus-Fermented red rice, is a PPARγ agonist with anti-inlfammatory activity. Ankaflavin exhibits selective cytotoxic effect and induces cell death on cancer cells.

Ankaflavin (0-50 μg/mL, 48 h) shows cytotoxicity against cancer cells with no significant toxicity toward normal cells.Ankaflavin (0-30 μg/mL, 0-48 h) arrests Hep G2 cell cycle at sub-G1 phase in a dose- and time-dependent manner.Ankaflavin (25 μg/mL, 48 h) induces Hep G2 cell apoptosis. Cell Cytotoxicity Assay Cell Line:A549, Hep G2, MRC-5 and WI-38 Concentration:1, 10, 25, and 50 μg/mL Incubation Time:48 h Result:Showed cytotoxicity against A549 and Hep G2 cells in a dose-dependent manner with no significant toxicity toward normal cells (MRC-5 and WI-38).Cell Cycle Analysis Cell Line:Hep G2 cells Concentration:15, 20, 25, and 30 μg/mLIncubation Time:12, 24, 36, and 48 hResult:Induced a distinct sub-G1 peak in Hep G2 cells in a dose- and time-dependent manner.Apoptosis AnalysisCell Line:Hep G2 cells Concentration:25 μg/mL Incubation Time:48 h Result:Exhibited significant chromatin condensation (fluorescent spot) through Hoechst staining.

Ankaflavin (10 mg/kg; p.o.; daily for 28 days) shows antidiabetic and anti-inflammatory activity, improves liver function and pancreatic function. Animal Model:Wistar rats (4 weeks of age), diabetes was induced by treating them with Methylglyoxal (MG) (600 mg/kg; oral) for 4 weeks Dosage:10 mg/kg Administration:Oral administration for 28 days Result:Exerted PPARγ agonist activity. Effectively reduced AGE (advanced glycation end-products) levels in serum, liver, and pancreas of MG-induced rats.

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Metabolic Enzyme/Protease

PPAR

PPARγ

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50980-32-0

386.48

C??H??O?

>98% (HPLC)

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O=C([C@@H]1C(CCCCCCC)=O)O[C@]2(C)[C@]1([H])CC(C=C(/C=C/C)OC3)=C3C2=O

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(-20℃)

With Ice Pack

≥ 2 years