Alliin

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

蒜氨酸是一种大蒜有机硫化合物，具有多种药理特性。蒜氨酸通过激活 PPARγ 来预防 LPS 诱导的 ALI，随后抑制 LPS 诱导的 NF-κB 激活和炎症反应。

Alliin is a garlic organosulfur compound that possesses various pharmacological properties.alliin protected against LPS-induced ALI by activating PPARγ which subsequently inhibited LPS-induced NF-κB activation and inflammatory response.?Alliin might be used as an anti-inflammatory agent in the treatment of ALI.

Cell Viability Assay Cell Line:HepG2 cells Concentration:10-1280 μM Incubation Time:24 h Result:Decreased the cell viability at concentrations from 320 μM to 1280 μM.Did not have cell toxicity at concentrations from 0 μM to 160 μM.Western Blot Analysis Cell Line:HepG2 cells Concentration:0-160 μM Incubation Time:23 hResult:Increased the expression of p-AMPK and decreased the protein expression of AMPK at concentrations of 80 μM and 160 μM.Inhibited the protein expression of SREBP-1, FAS, SREBP-2 and HMGCR by 1,3-DCP-induced at concentrations of 80 μM and 160 μM.Western Blot Analysis Cell Line:RAW264.7Concentration:100 μg/mL Incubation Time:6 h Result:Inhibited the protein expression ofiNOS, IL-1β, IL-6, and TNF-α, and the production of NO.Suppressed the expression of iNOS, TNF-α, IL-1β, and IL-6 mRNAs.Blocked JNK/ERK1/2-mediated transcriptional activation of PPARγ.

Animal Model:DSS colitis mouse model Dosage:500 mg/kg Administration:i.g., 10 days Result:Decrease hematochezia symptom and diarrhea symptom.Improved weight loss.Reduced colon injury and inflammatory cell infiltration, restored the structure of colon epithelial and crypt.Reduced the expression of iNOS, TNF-α and IL-6 mRNAs.

(S)-3-(Allylsulphinyl)-L-alanine

Metabolic Enzyme/Protease

PPAR

PPARγ|NF-κB

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556-27-4

177.22

C6H11NO3S

>98% (HPLC)

DMSO:3 mg/mL (16.92 mM)

N[C@@H](CS(=O)CC=C)C(O)=O

((S)-allylsulfinyl)-D-alanine

(-20℃)

With Ice Pack

≥ 2 years