Insulin Receptor

Insulin is an anabolic peptide hormone secreted by the b-cells of the pancreas that plays a critical role in the regulation of human metabolism.Insulin is widely viewed as a glucose homeostasis regulating hormone, it is now known to have a much broader pleiotropic role. An insulin-like signaling system exists in all metazoans, and regulates evolutionarily conserved processes including reproduction and lifespan.The receptor activates a complex intracellular signaling network through IRS proteins and the canonical PI3K and ERK cascades.Insulin signaling in the liver and b cell is emerging as the major determinant in preventing type 2 diabetes, through the integrative role of molecules like IRS2 and FOXO, preventing b cell dedifferentiation.


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