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14-3-3 Protein

The 14-3-3 protein was initially described as an acidic, abundant brain protein, they are a family of conserved regulatory molecules expressed in all eukaryotic cells. The name is derived from the combination of its fraction number on DEAE-cellulose chromatography and its migration position in the subsequent starch–gel electrophoresis. A striking feature of the 14-3-3 proteins is their ability to bind a multitude of functionally diverse signaling proteins, including kinases,phosphatases, and transmembrane receptors.

References:

1.Fu H, et al. Annu Rev Pharmacol Toxicol. 2000;40:617-47.