The nuclear receptors (NRs) are a large family of ligand-regulated transcriptional factors and include the receptors for steroid hormones, thyroid hormones, lipophilic vitamins, and cholesterol metabolites. Retinoic acid receptor-related orphan receptor (ROR) α, β and γ belong to the NR superfamily, the ROR subfamily of transcription factors consists of RORα (NR1F1), RORβ (NR1F2) and RORγ (NR1F3) and has been identified in several mammalian species that exhibit tissue-specific expression of these transcription factors. RORα is widely expressed in liver, skeletal muscle, skin, lung, adipose tissue, kidney, thymus, and brain. RORβ exhibits a more restricted neuronal-specific expression pattern in the brain, retina, and pineal gland. RORγ is highly expressed in thymus (the thymus-specific isoform is referred to as RORγt), muscle, testis, pancreas, prostate, heart, and liver.


1.Zhang Y, et al. Acta Pharmacol Sin. 2015;36(1):71–87.