Krüppel-like factors (KLFs) are deoxyribonucleic acid–binding transcriptional factors that regulate various pathways that control metabolism and other cellular mechanisms. KLF isoforms have been associated with regulation of metabolic pathways and energetic homeostasis in various organs, such as the liver, adipose tissue, heart, skeletal muscle, lungs, and myeloid cells. KLFs are critical regulators of physiological systems that include the cardiovascular, digestive, respiratory, hematological, and immune systems and are involved in disorders such as obesity, cardiovascular disease, cancer, and inflammatory conditions. Furthermore, KLFs play an important role in reprogramming somatic cells into induced pluripotent stem (iPS) cells and maintaining the pluripotent state of embryonic stem cells.


1.Nina M. Pollak et al.JACC Basic Transl Sci. 2018 Feb; 3(1): 132–156.
2.Beth B. McConnell and Vincent W. Yang.Physiol Rev. 2010 Oct; 90(4): 1337–1381.