Influenza Virus

There are two main types of influenza (flu) virus: Types A and B. Influenza A viruses can be broken down into sub-types depending on the genes that make up the surface proteins. Over the course of a flu season, different types (A & B) and subtypes (influenza A) of influenza circulate and cause illness. Influenza A viruses are further divided into subtypes distinguished by the antigenic properties of two viral surface glycoproteins, hemagglutinin (HA) and neuraminidase (NA). Influenza A virus M2 and influenza B virus M2 have little structural or sequence homology despite their functional similarity as proton channels. Thus, antiviral compounds with a high barrier to resistance that inhibit M2 of both types are required.


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