The GluCls, along with the HisCls, pHCl, and the vertebrate glycine receptors, belong to the subfamily of CysLGCC that possess two Cys loops in the N-terminal extracellular domain and are thus distinct from the GABA-gated channels present throughout the vertebrates and invertebrates. Glutamate-gated chloride channels (GluCls) are found only in protostome invertebrate phyla but are closely related to mammalian glycine receptors. They have a number of roles in these animals, controlling locomotion and feeding and mediating sensory inputs into behavior. The macrocyclic lactone (ML) group of anthelmintics, insecticides, and acaricides acts at GluCls, either activating the channels directly or potentiating their responses to glutamate. GluCls have a wide range of functions in invertebrate nervous systems, but these can be broadly divided into three interlinked categories: the control and modulation of locomotion, the regulation of feeding, and the mediation of sensory inputs.


1.Adrian J Wolstenholme. J Biol Chem. 2012 Nov 23; 287(48): 40232–40238.