Hepatitis C virus(HCV) is an enveloped, single-stranded RNA virus, belonging to the Flaviviridae family. HCV infection is a major cause of chronic hepatitis worldwide, leading to steatosis, liver cirrhosis and hepatocellular carcinoma. Significant advances in understanding the mechanism of HCV infection have been made since the development of  a cell system reproducing the complete HCV cell cycle in vitro. HCV represents a new paradigm in interactions between the virus and its target cell, the human hepatocyte, due to the centralrole of lipoproteins in the HCV life cycle. HCV cell entry is a multi-step process: heparan sulphate and/or low-density lipoprotein receptor are cell surface factors mediating an initial virus attachment; subsequent virus interaction with tetraspanin CD81 and the human scavenger receptor SR-BI, the main HCV receptors, tiggers virus movement to the tight junctions and its uptake via Claudin-1 and occluding.


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