Guanylate Cyclase

Soluble guanylate cyclase (sGC) is responsible for transducing the gaseous signaling molecule nitric oxide (NO) into the ubiquitous secondary signaling messenger cyclic guanosine monophosphate in eukaryotic organisms.  sGC converts 5′-guanosine triphosphate (GTP) to 3′,5′-cyclic guanosine monophosphate (cGMP). When NO binds to sGC, enzyme activity increases several hundredfold, transducing the gaseous paracrinesignaling molecule to a ubiquitous secondary signaling molecule.  Aberrations resulting in decreased function of this sGC-dependent signaling pathway have been linked to multiple pathologies, including cardiovascular disease, hypertension, asthma, and neurodegeneration.


1.Horst BG and Marletta MA. Nitric Oxide. 2018;77:65–74.