S-nitrosoglutathione reductase (GSNOR) is an important regulator of human health and disease. The modulation of protein S-nitrosation by GSNOR contributes to a host of maladies and can be exacerbated by the dysregulation of GSNOR. One of the most important is GSNOR’s regulation of GSNO, and by extension, nitric oxide ( NO) and protein S-nitrosation.  NO is a reactive nitrogen species (RNS) that is critical to the normal function of most cell types.GSNO can transfer its  NO moiety to a cysteine thiol, resulting in the posttranslational modification (PTM) S-nitrosation/S-nitrosylation. The dysregulation of GSNOR can significantly alter cellular homeostasis, leading to disease. GSNOR plays an important regulatory role in smooth muscle relaxation, immune function, inflammation, neuronal development and cancer progression, among many other processes.


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