11β-HSD
11β-HSD catalyze interconversion of active cortisol and corticosterone with inert cortisone and 11-dehydrocorticosterone. 11β-HSD type 1, a predominant reductase in most intact cells, catalyzes the regeneration of active glucocorticoids, thus amplifying cellular action; 11β-HSD2 is a high-affinity dehydrogenase that inactivates glucocorticoids. In the distal nephron, 11β-HSD2 ensures that only aldosterone is an agonist at mineralocorticoid receptors (MR).The 11β-HSDs thus illuminate the emerging biology of intracrine control, afford important insights into human pathogenesis, and offer new tissue-restricted therapeutic avenues.
References:
1.Chapman K, et al. Physiol Rev. 2013 Jul;93(3):1139-206.
References:
1.Chapman K, et al. Physiol Rev. 2013 Jul;93(3):1139-206.
Metabolic Enzyme/Protease
11β-HSD(15)
15-PGDH(1)
ACC(8)
ACE(7)
AChE(17)
Adenylate Cyclase(10)
ALDH(14)
Aldose Reductase(5)
Aminopeptidase(15)
BACE(15)
Casein Kinase(33)
CAT(5)
Cathepsin(8)
CETP(10)
COMT(2)
CPG2(1)
CYPs(6)
Decarboxylase(3)
Dehydrogenase(43)
DGAT(4)
Dopamine beta-hydroxylase(2)
DPP(20)
Elastase(6)
FAAH(10)
Factor Xa(20)
Fatty Acid Synthase(7)
Ftase(2)
FXR(16)
Glucokinase(1)
GSNOR(2)
Guanylate Cyclase(5)
HMGCR(11)
IDH(6)
IDO(12)
IMPDH(2)
LDH(2)
LDL(2)
Lipase(8)
Lipid(5)
MAGL(2)
MAO(38)
MMP(30)
NAMPT(5)
Neprilysin(4)
Other Targets(4)
P450(46)
PAI-1(5)
Phosphatase(24)
Phospholipase(18)
PPAR(56)
Protein Phosphatase/PTP(6)
Renin(7)
Retinoid Receptor(15)
SCD(4)
Steroid Sulfatase (STS)(2)
Thioredoxin(1)
TPH(5)
Transferase(10)
Vitamin(37)
Xanthine Oxidase (XAO)(1)