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11β-HSD

11β-HSD catalyze interconversion of active cortisol and corticosterone with inert cortisone and 11-dehydrocorticosterone. 11β-HSD type 1, a predominant reductase in most intact cells, catalyzes the regeneration of active glucocorticoids, thus amplifying cellular action; 11β-HSD2 is a high-affinity dehydrogenase that inactivates glucocorticoids. In the distal nephron, 11β-HSD2 ensures that only aldosterone is an agonist at mineralocorticoid receptors (MR).The 11β-HSDs thus illuminate the emerging biology of intracrine control, afford important insights into human pathogenesis, and offer new tissue-restricted therapeutic avenues.

References:

1.Chapman K, et al. Physiol Rev. 2013 Jul;93(3):1139-206.

Metabolic Enzyme/Protease

11β-HSD(15) 15-PGDH(1) ACC(8) ACE(7) AChE(15) Adenylate Cyclase(9) ALDH(14) Aldose Reductase(5) Aminopeptidase(15) BACE(13) Casein Kinase(28) CAT(5) Cathepsin(8) CETP(10) COMT(2) CPG2(1) CYPs(4) Decarboxylase(2) Dehydrogenase(33) DGAT(4) Dopamine beta-hydroxylase(2) DPP(20) Elastase(6) FAAH(9) Factor Xa(19) Fatty Acid Synthase(6) Ftase(2) FXR(15) Glucokinase(1) GSNOR(2) Guanylate Cyclase(4) HMGCR(11) IDH(6) IDO(9) IMPDH(2) LDH(2) LDL(2) Lipase(7) Lipid(5) MAGL(2) MAO(28) MMP(24) NAMPT(5) Neprilysin(4) Other Targets(3) P450(34) PAI-1(5) Phosphatase(14) Phospholipase(16) PPAR(47) Protein Phosphatase/PTP(6) Renin(7) Retinoid Receptor(13) SCD(2) Steroid Sulfatase (STS)(2) Thioredoxin(1) TPH(5) Transferase(9) Vitamin(35) Xanthine Oxidase (XAO)(1)