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11β-HSD

11β-HSD catalyze interconversion of active cortisol and corticosterone with inert cortisone and 11-dehydrocorticosterone. 11β-HSD type 1, a predominant reductase in most intact cells, catalyzes the regeneration of active glucocorticoids, thus amplifying cellular action; 11β-HSD2 is a high-affinity dehydrogenase that inactivates glucocorticoids. In the distal nephron, 11β-HSD2 ensures that only aldosterone is an agonist at mineralocorticoid receptors (MR).The 11β-HSDs thus illuminate the emerging biology of intracrine control, afford important insights into human pathogenesis, and offer new tissue-restricted therapeutic avenues.

References:

1.Chapman K, et al. Physiol Rev. 2013 Jul;93(3):1139-206.

Metabolic Enzyme/Protease

11β-HSD(15) 15-PGDH(1) ACC(8) ACE(7) AChE(17) Adenylate Cyclase(10) ALDH(14) Aldose Reductase(5) Aminopeptidase(15) BACE(15) Casein Kinase(33) CAT(5) Cathepsin(8) CETP(10) COMT(2) CPG2(1) CYPs(6) Decarboxylase(3) Dehydrogenase(43) DGAT(4) Dopamine beta-hydroxylase(2) DPP(20) Elastase(6) FAAH(10) Factor Xa(20) Fatty Acid Synthase(7) Ftase(2) FXR(16) Glucokinase(1) GSNOR(2) Guanylate Cyclase(5) HMGCR(11) IDH(6) IDO(12) IMPDH(2) LDH(2) LDL(2) Lipase(8) Lipid(5) MAGL(2) MAO(38) MMP(30) NAMPT(5) Neprilysin(4) Other Targets(4) P450(46) PAI-1(5) Phosphatase(24) Phospholipase(18) PPAR(56) Protein Phosphatase/PTP(6) Renin(7) Retinoid Receptor(15) SCD(4) Steroid Sulfatase (STS)(2) Thioredoxin(1) TPH(5) Transferase(10) Vitamin(37) Xanthine Oxidase (XAO)(1)